Genetic analysis of DNA methylation and gene expression levels in whole blood of healthy human subjects

BMC Genomics

Table 1 Number of probes constituting significant methylation and expression combinations and their association with SNPs

	unique	+	-	overlap	SNP *cis*
				Cis associations
Methylation	517	224	354	61	69 probes (13.3%), 86 independent loci
Expression	495	214	336	55	62 probes (12.5%), 73 independent loci
				Trans associations
Methylation	705	585	230	110	1 probe (<1%)
Expression	170	101	117	48	0 probes

This table shows the significant methylation and expression combinations, subdivided into cis and trans associations. The first column shows the counts of unique probes (for methylation and expression). The second and third columns indicate the number of probes positively (+) or negatively (−) associated. The fourth column indicates the overlapping probes: methylation or expression probes that are associated with expression or methylation levels in both directions. The last column indicates the number (and %) of unique probes associated with SNPs and the number of independent (pruned r² of 0.2) loci in cis.

ISSN: 1471-2164