Genetic analysis of DNA methylation and gene expression levels in whole blood of healthy human subjects

BMC Genomics

Table 4 Top GO enrichment terms for expression modules

Module	Size	Rank	p.Bonf	Fraction	Ontology	Term name
1	1520	1	1.20E-14	0.65147	CC	membrane-bounded organelle
1	1520	2	1.90E-14	0.65007	CC	intracellular membrane-bounded organelle
2	703	1	1.30E-05	0.04885	CC	ribosome
2	703	2	1.50E-05	0.07481	BP	translation
3	658	1	0.00018	0.16382	CC	extracellular region
4	647	1	0.011	0.63711	CC	membrane-bounded organelle
6	442	1	7.60E-07	0.27229	BP	response to stress
6	442	2	2.80E-06	0.34217	BP	signal transduction
7	426	1	9.40E-07	0.18734	BP	immune system process
8	407	1	0.0042	0.66755	CC	intracellular membrane-bounded organelle
9	387	1	1.70E-05	0.82961	CC	intracellular part
10	355	1	1.80E-05	0.07855	BP	ncRNA metabolic process
10	355	2	3.60E-05	0.19335	CC	mitochondrion
12	306	1	2.00E-16	0.1134	CC	ribosome
12	306	2	4.00E-16	0.17182	CC	ribonucleoprotein complex
12	306	3	1.20E-14	0.14777	BP	translation
12	306	4	2.30E-14	0.09278	BP	viral transcription
13	260	1	0.00041	0.025	CC	hemoglobin complex
13	260	2	0.011	0.025	BP	heme biosynthetic process
14	237	1	0.014	0.61086	MF	protein binding
15	118	1	0.018	0.25688	BP	intracellular signal transduction
15	118	2	0.032	0.12844	BP	small GTPase mediated signal transduction
16	108	1	1.30E-05	0.18478	BP	translation
16	108	2	0.00017	0.1087	BP	ribosome biogenesis
17	99	1	2.30E-09	0.36957	CC	mitochondrion
18	72	1	3.30E-06	0.1791	BP	platelet activation
18	72	2	1.20E-05	0.22388	BP	blood coagulation
19	60	1	1.40E-17	0.31034	MF	structural constituent of ribosome
19	60	2	2.90E-17	0.32759	CC	ribosome
20	52	1	7.10E-23	0.32653	BP	type I interferon-mediated signaling pathway
20	52	2	7.10E-23	0.32653	BP	cellular response to type I interferon
23	32	1	0.053	0.17241	CC	external side of plasma membrane

For each module we list the top enriched GO terms. Columns list the module label, module size, rank of the enrichment p-value for that particular module, the Bonferroni-corrected enrichment p-value (the correction is performed with respect to the number of GO terms), fraction of the module genes also in the GO term, GO ontology, and GO term name. Multiple expression modules exhibit significant enrichment. Row shading separates modules for easier reading. The enrichment provides evidence that the modules are biologically meaningful.

ISSN: 1471-2164