Figure 4

Group A proteins downregulated and predicted to be targeted by miR17-92 cluster members. (A) miR-17-92 cluster expression increases as growth rate increases. (B) Normalised CIA score plot showing the divergence between mRNA and protein expression profiles for miR17-92 TargetScan predictions. Each predicted target is represented by an arrow, the length of which corresponds to the divergence between mRNA (circular base) and protein (arrowhead) expression across the dataset. Potential miRNA 17–92 cluster mediated post-transcriptional repression of (C) DDX5, (D) MAN2A1 and (E) CFL2. For each of the three targets the mRNA expression (red) remains constant while the protein expression decreases (blue) for the 24 samples were both mRNA and protein data was available. The conserved (human, mouse, rat and CHO) binding site to the seed region of the miRNA cluster is shown to the right for each protein.