Figure 3From: Nuclear genomic control of naturally occurring variation in mitochondrial function in Drosophila melanogasterGenetic variation in the sls gene associates with mitochondrial function. (Panel A) The top panel shows the sls SNPs (x-axis) associated with mitochondrial state 3 (empty circle), state 4 (filled circle), and P:O ratio (triangle) at a nominal P-value (−Log10 (P), y-axis) of ≤ 1 × 10-4. The bottom panel reports a schematic representation of the sls gene on the third chromosome at cytological position 62C2-62C4 (NCBI Accession number AE014296.4) and of two alternative sls transcripts (sls-RP and sls-RA). The location of the p[XP] insertion sites that create the slsd00134 and slsd07587 mutations are indicated with an orange and blue arrowhead, respectively. (Panels B-D) In the analysis averaged across sexes, homozygous slsd00134 flies had lower state 3 (F1,38 = 5.37; P = 0.026) (Panel B) and higher state 4 (F1,39 = 4.32; P = 0.045) (Panel C) respiration rates than controls. Homozygous slsd07587 flies had lower state 3 respiration rates than controls (F1,35 = 20,61; P < 0.0001) (Panel D). In all panels, error bars represent standard errors for n = 14–24 independent replicates. Statistical significance was determined by a two-way ANOVA.Back to article page