MirSNP, a database of polymorphisms altering miRNA target sites, identifies miRNA-related SNPs in GWAS SNPs and eQTLs

Table 1 Brain eQTLs found in predicted miRNA-mRNA binding sites

mirSNP	Gene	Involved miRNAs	Allele	eQTL	Linkage^a	p-value (Myers, A.J. et al)^b	p-value (Colantuoni, C. et al)^c	p-value (Gibbs, J.R. et al)^d
rs3087822	CRIPT	hsa-miR-200a-3p, hsa-miR-26b-3p, hsa-miR-29b-1-5p, hsa-miR-335-3p	A/G	rs3087822	1	8.45E-05	9.54E-18	3.20E-13
rs13042	FAM82B	hsa-miR-202-5p, hsa-miR-362-5p, hsa-miR-500b, hsa-miR-1914-5p	A/G^e	rs13042/rs4961193	1/0.864	5.03E-06	8.52E-16	1.30E-08
rs1058381	RABEP1	hsa-miR-4760-3p	A/G	rs1058381/rs1065483	1/0.954	0.00254	7.81E-19	2.89E-08
rs1058398	RABEP1	hsa-miR-134, hsa-miR-3118, hsa-miR-943, hsa-miR-192-3p, hsa-miR-5002-3p	A/G	rs1065483	0.955	0.00254	7.81E-19	3.92E-10

^aLinkage analysis of predicted miRNA-related SNPs and eQTLs in 90 CEU individuals from HapMap project.
^bA survey of gene expression of 193 normal human brain tissues (cortex) [22]. The p-values have been adjusted by Bonferroni correction.
^cA survey of gene expression of 269 normal human brain tissues (prefrontal cortex) [23]. Genome-wide Bonferroni corrected p = 0.05 (2.6e-12).
^dA survey of gene expression of 150 normal human brain tissues (cerebellum, frontal cortex, pons, and temporal cortex) [24].
^eAlthough rs13042 has four allelotypes in MirSNP, only A and G alleles have frequencies in populations.

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