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Table 1 Brain eQTLs found in predicted miRNA-mRNA binding sites

From: MirSNP, a database of polymorphisms altering miRNA target sites, identifies miRNA-related SNPs in GWAS SNPs and eQTLs

mirSNP Gene Involved miRNAs Allele eQTL Linkagea p-value (Myers, A.J. et al)b p-value (Colantuoni, C. et al)c p-value (Gibbs, J.R. et al)d
rs3087822 CRIPT hsa-miR-200a-3p, hsa-miR-26b-3p, hsa-miR-29b-1-5p, hsa-miR-335-3p A/G rs3087822 1 8.45E-05 9.54E-18 3.20E-13
rs13042 FAM82B hsa-miR-202-5p, hsa-miR-362-5p, hsa-miR-500b, hsa-miR-1914-5p A/Ge rs13042/rs4961193 1/0.864 5.03E-06 8.52E-16 1.30E-08
rs1058381 RABEP1 hsa-miR-4760-3p A/G rs1058381/rs1065483 1/0.954 0.00254 7.81E-19 2.89E-08
rs1058398 RABEP1 hsa-miR-134, hsa-miR-3118, hsa-miR-943, hsa-miR-192-3p, hsa-miR-5002-3p A/G rs1065483 0.955 0.00254 7.81E-19 3.92E-10
  1. aLinkage analysis of predicted miRNA-related SNPs and eQTLs in 90 CEU individuals from HapMap project.
  2. bA survey of gene expression of 193 normal human brain tissues (cortex) [22]. The p-values have been adjusted by Bonferroni correction.
  3. cA survey of gene expression of 269 normal human brain tissues (prefrontal cortex) [23]. Genome-wide Bonferroni corrected p = 0.05 (2.6e-12).
  4. dA survey of gene expression of 150 normal human brain tissues (cerebellum, frontal cortex, pons, and temporal cortex) [24].
  5. eAlthough rs13042 has four allelotypes in MirSNP, only A and G alleles have frequencies in populations.