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Table 1 Glossary of parameters

From: Weighted pedigree-based statistics for testing the association of rare variants

Notations Meaning
subscript Individuals
i, j = 1,…,n  
subscript k = 1,…,m variant/marker
s Iteration
p k frequency of the reference allele of the k-th variant
x ik  = 0,1,2 indicator variable of genotype for the k-th variant of the i-th individual
Φ kinship matrix
superscript T matrix transpose
z i indicator variable of presence of rare variants in the region for the i-th individual
h i inbreeding coefficient of individual i
γ2k, γ1k relative risks
P corr correction factor in the test statistics accounting for the relatedness
n G number of controls
n c number of cases
p Pr(presence of rare variants in the genomic region)
T C population-based collapsing test statistic
T CF family-based collapsing test statistic
T WSS population-based weighted sum statistic
T WSSF family-based weighted sum statistic
T VT population-based variant threshold statistic
T VTF family-based variant threshold statistic