Weighted pedigree-based statistics for testing the association of rare variants

BMC Genomics

Table 2 Type I error rates

Study Design	Nominal Level	Estimated Kinship Coefficient	Theoretic Kinship Coefficient	Without Correction for Relatedness
Population Design with equal number of case and control	0.050	0.0515	0.0480	0.0505
	0.010	0.0096	0.0099	0.0099
	0.001	0.0010	0.0010	0.0010
Mixed family and case–control design	0.050	0.0504	0.0494	0.0620
	0.010	0.0102	0.0097	0.0160
	0.001	0.0010	0.0010	0.0015
Sib-pair-1	0.050	0.0486	0.0475	0.0813
	0.010	0.0097	0.0092	0.0129
	0.001	0.0010	0.0011	0.0012
Nuclear-family-1	0.050	0.0531	0.0497	0.0829
	0.010	0.0093	0.0093	0.0107
	0.001	0.0010	0.0009	0.0014
Three-generation-1	0.050	0.0512	0.0484	0.0874
	0.010	0.0094	0.0102	0.0099
	0.001	0.0010	0.0010	0.0019

5000 replicates were conducted to calculate type I error rates for each study design.

ISSN: 1471-2164