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Table 3 Power of mixed and unmixed study designs

From: Weighted pedigree-based statistics for testing the association of rare variants

  Sample Size and Power
Uniform Data Design      
Sib-Pair-2 900 1200 1500 1800 2100
χ2 0.37 0.48 0.52 0.55 0.57
Collapsing 0.51 0.58 0.62 0.66 0.69
VT 0.6 0.68 0.73 0.77 0.79
WSS 0.61 0.7 0.74 0.78 0.81
Nuclear Family 2 900 1200 1500 1800 2100
χ2 0.40 0.50 0.54 0.57 0.59
Collapsing 0.52 0.60 0.64 0.67 0.70
VT 0.62 0.70 0.76 0.79 0.80
WSS 0.63 0.72 0.78 0.81 0.82
Three Generation 2 900 1200 1500 1800 2100
χ2 0.44 0.53 0.57 0.6 0.63
Collapsing 0.54 0.62 0.67 0.7 0.73
VT 0.64 0.71 0.79 0.82 0.84
WSS 0.65 0.74 0.8 0.84 0.85
Mixed Data Designs      
Mix1 (33% Sib-Pair-2, 33% nuclear-2, and 34% Three- generation-2) 900 1200 1500 1800 2100
χ2 0.39 0.51 0.53 0.56 0.60
Collapsing 0.53 0.59 0.64 0.68 0.70
VT 0.62 0.68 0.73 0.77 0.82
WSS 0.62 0.69 0.75 0.81 0.84
Mix2 (50% Sib-Pair-2 and 50% Nuclear Family-2) 900 1200 1500 1800 2100
χ2 0.36 0.45 0.50 0.55 0.58
Collapsing 0.49 0.55 0.59 0.63 0.65
VT 0.59 0.68 0.74 0.78 0.82
WSS 0.6 0.69 0.76 0.8 0.83