Skip to main content

Table 3 Differential expression of genes encoding secretory pathway related proteins

From: The transcriptomic fingerprint of glucoamylase over-expression in Aspergillus niger

DSM code

DSM annotation

Fold-change B36/N402

P

FDR

Protein folding

    

An02g14800*

protein disulfide isomerase A pdiA – A. niger

1.72

5.98E-08

3.43E-06

An18g02020*

disulfide isomerase tigA – A. niger

1.89

1.61E-08

1.17E-06

An01g04600*

PDI related protein A prpA – A.niger

2.08

2.21E-09

2.40E-07

An16g07620*

strong similarity to endoplasmic reticulum oxidising protein Ero1 – S. cerevisiae

1.97

1.02E-08

8.15E-07

An18g04260*

similarity to secreted protein HNTME13 from patent WO9839446-A2 – H. sapiens

2.46

1.06E-09

1.28E-07

An18g06470*

strong similarity to DnaJ-like protein MTJ1 - Mus musculus

1.48

1.34E-06

3.70E-05

An05g00880*

strong similarity to dnaJ protein homolog Scj1 – S. cerevisiae

1.79

1.02E-07

5.04E-06

An01g08420*

strong similarity to calcium-binding protein precursor clx1p – S. pombe

2.42

8.96E-10

1.13E-07

An04g02020*

strong similarity to cyclophilin cypB – A. nidulans

1.69

1.19E-07

5.60E-06

An01g06670*

strong similarity to peptidyl-prolyl isomerase FKBP-21 – N. crassa

1.66

4.71E-07

1.57E-05

An11g04180*

dnaK-type molecular chaperone bipA – A. niger

2.32

8.63E-10

1.11E-07

An01g13220*

strong similarity to 150 kDa oxygen regulated protein ORP150 - Rattus norvegicus

2.26

1.34E-09

1.58E-07

Signal recognition/cleavage

   

An04g06890

similarity to 72-kD protein of the signal recognition particle SRP72 - Canis lupus

1.33

1.14E-04

1.37E-03

An15g06470*

similarity to signal sequence receptor alpha chain - Canis lupus

1.86

4.49E-08

2.72E-06

An01g00560*

strong similarity to signal peptidase subunit Sec11 – S. cerevisiae

1.84

5.70E-07

1.84E-05

An16g07390*

strong similarity to endoplasmatic reticulum signal peptidase subunit Spc2 – S. cerevisiae

1.90

7.99E-09

6.74E-07

An09g05420*

similarity to signal peptidase subunit Spc3 – S. cerevisiae

1.99

6.90E-09

6.03E-07

Translocation into ER

   

An03g04340*

strong similarity to ER membrane translocation facilitator Sec61 - Yarrowia lipolytica

1.68

9.76E-08

4.90E-06

An01g03820

strong similarity to ER protein-translocation complex subunit Sbh2 – S. cerevisiae

1.62

2.60E-06

6.33E-05

An01g11630*

strong similarity to translocation complex component Sss1 – S. cerevisiae

1.71

1.88E-07

8.11E-06

An02g01510*

strong similarity to component of the endoplasmic reticulum protein translocation machinery Sec62 – S. cerevisiae

1.57

7.50E-06

1.49E-04

An01g13070*

strong similarity to signal recognition particle receptor Sec63 – S. cerevisiae

2.02

2.17E-08

1.47E-06

An16g08830*

strong similarity to component of ER protein-translocation subcomplex Sec71 from patent WO9949028-A1 – S. cerevisiae

1.80

3.47E-08

2.17E-06

An15g01670

strong similarity to signal sequence receptor alpha subunit SRP101 - Yarrowia lipolytica

1.29

1.14E-04

1.37E-03

An05g00140*

similarity to signal recognition particle receptor beta chain Srp102 – S. cerevisiae

1.39

2.57E-05

4.16E-04

Glycosylation

   

An02g07650

strong similarity to phosphoglucomutase pgmB – A. nidulans

0.80

5.29E-04

4.81E-03

An03g05940*

strong similarity to glutamine-fructose-6-phosphate transaminase Gfa1 – S. cerevisiae

0.66

2.20E-06

5.58E-05

An04g04990*

strong similarity to mannose-1-phosphate guanyltransferase MPG1 - Trichoderma reesei

1.46

1.44E-05

2.57E-04

An11g02380*

strong similarity to GTP:alpha-D-mannose-1-phosphate guanylyltransferase MPG1 - Hypocrea jecorina

1.35

5.47E-05

7.67E-04

An02g08660

strong similarity to hypothetical protein H04M03.4 - Caenorhabditis elegans

1.25

2.90E-04

2.91E-03

An03g06940*

strong similarity to UPD-GlcNAc transporter MNN2-2 - Kluyveromyces lactis

1.35

2.72E-05

4.38E-04

An02g14560*

oligosaccharyltransferase alpha subunit OstA – A. niger

2.05

2.27E-09

2.40E-07

An07g04190*

strong similarity to dolichyl-diphospho-oligosaccharide--protein glycosyltransferase 48kD chain DDOST - Gallus gallus

1.69

1.03E-07

5.04E-06

An18g03920*

strong similarity to defender against apoptotic cell death DAD1 - Homo sapiens

2.04

2.49E-09

2.56E-07

An02g14930*

strong similarity to dolichyl-diphosphooligosaccharide-protein glycotransferase gamma chain Ost3 - S. cerevisiae

1.47

1.51E-06

4.08E-05

An16g08570*

strong similarity to translation initiation factor 3 47 kDa subunit stt3p – S. pombe

1.78

2.74E-07

1.07E-05

An16g04330*

strong similarity to mannose phospho-dolichol synthase dpm1 - Hypocrea jecorina

1.63

2.72E-07

1.07E-05

An01g05200*

strong similarity to DPM2 - Mus musculus

1.43

4.84E-05

6.98E-04

An03g04410*

strong similarity to UDP-glucose:dolichyl-phosphate glucosyltransferase Alg5 – S. cerevisiae

1.78

3.47E-07

1.26E-05

An02g03240*

strong similarity to UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase Alg7 – S. cerevisiae

1.92

1.76E-08

1.24E-06

An06g01100*

strong similarity to mannosyltransferase Alg1 – S. cerevisiae

1.27

1.50E-04

1.70E-03

An14g05910*

strong similarity to mannosyltransferase Alg2 – S. cerevisiae

1.93

2.28E-08

1.53E-06

An18g05910*

strong similarity to hypothetical glycosyl transferase SPCC330.08 – S. pombe

1.49

7.14E-05

9.49E-04

An02g14940*

strong similarity to human transmembrane protein HTMPN-23 from patent WO9961471-A2 - Homo sapiens

1.49

2.62E-06

6.38E-05

An04g03130

strong similarity to mannosylation protein Lec35 - Cricetulus griseus [putative sequencing error]

1.56

4.25E-07

1.46E-05

An18g02360*

strong similarity to Dol-P-Man dependent alpha(1–3) mannosyltransferase Alg3 – S. cerevisiae

1.92

1.74E-08

1.24E-06

An08g07020*

similarity to mannosyl transferase Alg9 – S. cerevisiae

1.48

7.80E-06

1.53E-04

An01g08460*

strong similarity to the mannosyltransferase Alg12 – S. cerevisiae

1.37

4.69E-04

4.36E-03

An02g12630*

strong similarity to glucosyltransferase Alg6 - S. cerevisiae

1.37

1.35E-05

2.44E-04

An04g08820*

strong similarity to glucosyltransferase Alg8 – S. cerevisiae

1.24

3.24E-04

3.22E-03

An02g02980*

strong similarity to protein influencing Itr1 expression Die2 – S.s cerevisiae

1.42

4.53E-05

6.58E-04

An15g01420*

strong similarity to glucosidase I Cwh41 – S. cerevisiae

1.81

2.90E-08

1.84E-06

An18g05620

strong similarity to glucosidase II alpha subunit AAF66685.1 - Homo sapiens

0.80

4.70E-04

4.37E-03

An01g10930*

strong similarity to enzyme with sugar transferase activity from patent JP11009276-A - Acremonium sp.

0.45

2.27E-09

2.40E-07

An04g06920*

extracellular alpha-glucosidase aglU - Aspergillus niger

0.60

7.55E-08

4.07E-06

An09g03300

strong similarity to alpha-xylosidase XylS - Sulfolobus solfataricus

0.80

4.19E-04

3.98E-03

An09g05880*

strong similarity to alpha-glucosidase ModA - Dictyostelium discoideum

1.75

4.77E-08

2.86E-06

An13g00620*

strong similarity to 80K protein H precursor G19P1 - Homo sapiens

1.53

1.24E-06

3.47E-05

An07g06430*

strong similarity to glycoprotein glucosyltransferase gpt1p – S. pombe

1.64

3.96E-07

1.39E-05

An01g12550

strong similarity to mannosyl-oligosaccharide 1,2-alpha-mannosidase msdS – A. saitoi

0.32

2.29E-11

8.76E-09

An06g01510

strong similarity to class I alpha-mannosidase AAB62720.1 - Spodoptera frugiperda

0.74

4.29E-05

6.31E-04

An12g00340*

similarity to alpha 1,2-mannosidase IB - Homo sapiens

1.54

7.61E-06

1.50E-04

An05g01750

strong similarity to alpha-1,6-mannosyltransferase Hoc1 – S. cerevisiae

0.52

1.04E-08

8.30E-07

An11g07490

similarity to alpha-1,6-mannosyltransferase Hoc1 – S. cerevisiae

0.66

8.04E-07

2.46E-05

An15g03330

strong similarity to galactosyltransferase Bed1 – S. cerevisiae

1.42

9.62E-05

1.20E-03

An11g09890*

strong similarity to mannosyltransferase 1 PMT1 - Candida albicans

1.36

1.27E-04

1.49E-03

An07g10350*

protein O-mannosyl transferase pmtA – A. niger

1.50

4.45E-06

9.69E-05

An16g08490*

strong similarity to dolichyl-phosphate-D-mannose--protein O-mannosyltransferase Pmt4 – S. cerevisiae

1.49

1.89E-06

4.90E-05

An15g04810

similarity to alpha-1,3-mannosyltransferase Mnt2 - S. cerevisiae

0.75

2.96E-05

4.66E-04

An02g11720

strong similarity to alpha-mannosidase msd2 – A. nidulans

0.71

1.64E-05

2.85E-04

An01g06500

strong similarity to filamentous growth protein Dfg5 – S. cerevisiae

0.58

1.44E-05

2.56E-04

An02g02660

strong similarity to hypothetical protein Dcw1 – S. cerevisiae

0.78

2.74E-04

2.79E-03

An11g01240*

similarity to filamentous growth protein Dfg5 – S. cerevisiae

2.17

1.48E-08

1.10E-06

Protein misfolding (UPR and ERAD associated degradation)

An08g00830

strong similarity to protein phosphatase type 2C Ptc2 – S. cerevisiae

1.31

5.07E-04

4.65E-03

An11g11250*

strong similarity to interferon-induced double-stranded RNA-activated protein kinase inhibitor P58 - Homo sapiens

1.80

2.58E-07

1.03E-05

An01g14100*

weak similarity to stress protein Herp - Mus musculus

1.61

1.12E-06

3.21E-05

An03g04340*

strong similarity to ER membrane translocation facilitator Sec61 – Yarrowia lipolytica

1.68

9.76E-08

4.9E-06

An04g00360*

strong similarity to transport vesicle formation protein Sec13 – S. cerevisiae

1.84

1.28E-08

9.9E-07

An15g00640*

strong similarity to hypothetical protein GABA-A receptor epsilon subunit – Caenorhabditis elegans

2.03

6.20E-08

3.53E-06

An16g07970*

similarity to autocrine motility factor receptor Amfr – Mus musculus

1.60

1.09E-05

2.02E-04

An12g00340*

similarity to alpha 1,2-mannosidase IB - Homo sapiens

1.54

7.61E-06

1.50E-04

An15g01420*

strong similarity to glucosidase I Cwh41 – S. cerevisiae

1.81

2.90E-08

1.84E-06

An18g06220*

strong similarity to alpha-mannosidase Mns1 – S. cerevisiae

2.10

3.47E-06

8.05E-05

An01g12720*

similarity to tumour suppressor protein TSA305 from patent WO9928457-A1 - Homo sapiens

1.69

3.91E-07

1.38E-05

Protein complex involved in protein transport

   

An01g03190

similarity to protein Sec3 – S. cerevisiae

1.30

7.93E-05

1.03E-03

An08g05570*

similarity to secretory protein Sec5 – S. cerevisiae

1.54

1.97E-06

5.07E-05

An04g06180

strong similarity to exocyst subunit Sec6 – S.s cerevisiae

1.38

7.87E-05

1.03E-03

An08g07370

similarity to exocyst protein Exo84 – S. cerevisiae

1.42

9.83E-05

1.22E-03

An02g14400*

strong similarity to hypothetical protein SPCC338.13 – S. pombe

1.43

8.59E-06

1.66E-04

An16g01630

strong similarity to enoyl reductase of the lovastatin biosynthesis lovC – A.terreus

0.35

1.66E-10

3.53E-08

An04g08690*

similarity to polynucleotide sequence SEQ ID NO:3913 from patent WO200058473-A2 - Homo sapiens

1.37

7.88E-05

1.03E-03

An02g07090*

strong similarity to ASNA1 product arsenite translocating ATPase - Homo sapiens

1.30

1.46E-04

1.66E-03

An01g14250*

strong similarity to delta subunit of the coatomer delta-coat protein CopD - Bos taurus

1.46

3.66E-06

8.35E-05

An08g01250*

weak similarity to COP1-interacting protein 7 CIP7 - Arabidopsis thaliana

1.75

4.69E-07

1.57E-05

An16g05370*

similarity to zinc-finger protein Glo3 - S. cerevisiae

1.59

1.28E-05

2.34E-04

An16g02460*

strong similarity to alpha subunit of the coatomer complex Ret1 – S. cerevisiae

1.67

2.40E-07

9.68E-06

An01g14260*

strong similarity to delta subunit of the coatomer delta-coat protein CopD - Bos taurus [deleted ORF]

1.51

1.15E-06

3.27E-05

An12g04830*

strong similarity to coatomer protein zeta chain Ret3 – S. cerevisiae

1.47

7.15E-06

1.44E-04

An07g06030*

strong similarity to coatomer gamma subunit 2 copg2 - Homo sapiens

1.65

4.32E-06

9.45E-05

An02g05870*

strong similarity to coatomer beta subunit copB2 - Homo sapiens [putative frameshift]

1.50

1.17E-04

1.40E-03

An01g04040*

secretion-associated GTP-binding protein sarA – A. niger

1.27

1.99E-04

2.13E-03

An08g03270*

strong similarity to beta-COP Sec26 – S. cerevisiae

1.48

2.84E-06

6.82E-05

An04g00360*

strong similarity to transport vesicle formation protein Sec13 – S. cerevisiae

1.84

1.28E-08

9.90E-07

An02g01690*

strong similarity to p150 component of the COPII coat of secretory pathway vesicles Sec31 – S. cerevisiae

1.60

2.05E-07

8.64E-06

An01g04730*

strong similarity to secretory protein Sec23 – S. cerevisiae

1.62

2.83E-07

1.08E-05

An08g10650*

strong similarity to transport protein Sec24 – S. cerevisiae

1.55

6.97E-07

2.18E-05

An16g03320*

strong similarity to transport protein Sec24A - Homo sapiens

1.56

2.27E-06

5.69E-05

An15g01520*

strong similarity to multidomain vesicle coat protein Sec16 – S. cerevisiae

1.53

1.74E-06

4.55E-05

ER to Golgi and intra-Golgi transport

   

An08g03590*

strong similarity to precursor of protein Emp24 – S. cerevisiae

1.39

7.73E-06

1.52E-04

An09g05490*

strong similarity to COP-coated vesicle membrane protein P24 homolog lbrA - Polysphondylium pallidum

1.42

4.30E-06

9.43E-05

An07g09160

strong similarity to pattern formation protein cni - Drosophila melanogaster

1.28

1.30E-04

1.52E-03

An01g08870*

strong similarity to component of COPII-coated vesicles Erv25 - S. cerevisiae

1.39

7.23E-06

1.45E-04

An08g03960*

strong similarity to hypothetical endoplasmic reticulum associated protein – S. pombe

1.55

7.36E-06

1.47E-04

An03g04940*

strong similarity to Erv41 - S. cerevisiae

2.12

1.20E-08

9.44E-07

An01g04320*

strong similarity to COPII vesicle coat component protein Erv46 - S. cerevisiae

2.12

7.61E-09

6.57E-07

An02g02830

strong similarity to protein RER1 - Homo sapiens

1.30

5.22E-05

7.42E-04

An07g02190

strong similarity to protein Sec7 - S. cerevisiae

1.44

9.50E-06

1.81E-04

An08g06780*

strong similarity to transport protein Uso1 - S. cerevisiae

1.52

2.93E-06

7.00E-05

An18g06440

strong similarity to COPII vesicle component Yip3 - S. cerevisiae

1.67

2.58E-06

6.30E-05

An04g01780*

strong similarity to hypothetical protein YAR002c-a - S. cerevisiae

1.54

1.03E-06

3.00E-05

An04g08830*

similarity to Golgi membrane protein Emp47 - S. cerevisiae

1.69

9.30E-07

2.78E-05

An02g04250*

similarity to protein p58 - Rattus norvegicus

1.77

2.01E-08

1.39E-06

An04g01990*

similarity to protein ZW10 homolog HZW10 - Homo sapiens

1.32

1.06E-04

1.29E-03

An04g06090

similarity to geranylgeranyltransferase type-II alpha chain Bet4 - S. cerevisiae

0.77

2.69E-04

2.75E-03

An08g00290*

strong similarity to golgin-160 related protein Rud3 - S. cerevisiae

1.52

1.11E-05

2.05E-04

An08g06330*

strong similarity to epsilon-COP - Cricetulus griseus

1.39

1.84E-05

3.14E-04

An07g07340*

strong similarity to luminal ER-protein retention receptor ERD2 - Kluyveromyces marxianus

1.65

2.00E-07

8.46E-06

Other processes in the secretory pathway

   

An07g02170*

similarity to transport protein Bos1 - S. cerevisiae

1.91

1.65E-08

1.18E-06

An15g01380*

strong similarity to Synaptobrevin homolog v-SNARE Sec22 - S. cerevisiae

1.30

2.74E-04

2.78E-03

An18g02490*

strong similarity to ARF guanine-nucleotide exchange factor 2 Gea2 - S. cerevisiae

1.31

1.52E-04

1.71E-03

An07g08220*

strong similarity to clathrin associated epsin 2A - Homo sapiens

1.39

1.58E-05

2.76E-04

An02g08450*

secretory gene nsfA - Aspergillus niger

1.27

2.86E-04

2.89E-03

An02g14450*

secretory pathway Ca2+−ATPase pmrA - Aspergillus niger

1.51

3.12E-06

7.38E-05

An16g08470*

similarity to hypothetical cell growth regulator OS-9 - Homo sapiens

1.76

8.57E-07

2.58E-05

An02g03460*

similarity to hypothetical protein YIL041w - S. cerevisiae

1.31

1.49E-04

1.68E-03

An04g02070

strong similarity to clathrin heavy chain - Bos taurus

1.30

1.09E-04

1.33E-03

An06g01200*

strong similarity to endosomal protein Emp70 - S. cerevisiae

1.55

1.37E-06

3.77E-05

An01g11960

similarity to brefeldin A resistance protein Bfr1 - S. cerevisiae

1.44

1.27E-05

2.33E-04

An04g01950*

strong similarity to zinc-metalloprotease Ste24 - S. cerevisiae

1.63

1.61E-07

7.12E-06

  1. DSM code: ORF identifier in A. niger CBS 513.88 genome sequence [3]. Genes in bold are also found in maltose/xylose transcriptomic comparison [23]. * Indicates genes that were also identified in strains with constitutively active hacACA[36].
Back to article page

BMC Genomics

ISSN: 1471-2164

Contact us