Synergistic regulation of CNV-miRNAs. (A) Schematic representation of five genes regulated by both CNV-miRNA-α and CNV-miRNA-β. (B) Distribution of genes affected by two pseudo-CNV-miRNAs in 1000 simulations. The arrow on the right hand side represents the observed number of targets of two CNV-miRNAs. (C) Distribution of genes targeted by the two non-independent CNV-miRNAs in 1,000 random simulations. (D) Distribution of CNV-miRNAs as a result of dosage-balance from synergistic regulation.