Major gene networks specifically modulated by TSA at 6h. The IPA merged the top seven networks of TSA-elicited genes into a single network. The dominant nodes of TGFβ, HNF-4A, TNFα and MYC connected extensively to the signaling node of NFkB are highlighted. The major gene networks are either directly (solid lines) or indirectly (broken lines) connected to PI3K- and MAPK-specific signaling pathways. The up regulated genes are shown in pink and red while down-regulated genes are depicted in green.