DEGs common to TSA and CBHA at 6h | |||
---|---|---|---|
KEGG pathway | Gene nos | Entrez Gene IDs | P value |
MAPK signaling pathway | 7 | FGF7, FGF8, MKNK2, NFAT4,TGFb3, | P=2.02e-3 |
CD14, MAPKI8P1 | |||
Adipocytokine signaling pathway | 5 | CPT1A, PEPCK, ACSL5, ADIPOR2, CAMKK1, | P=9.51e-5 |
Purine metabolism | 5 | NME6, GMPR, IMPDH2, POLD3, POLR3F | P=2.90e-3 |
Cell cycle | 5 | TGFb3, CUL1, CCNA2, CCNB2, CDC20 | P=8.67e-4 |
Phosphatidylinositol signaling system | 4 | IMPA2, INPP4A, PIK3C2A, ITPKA | P=1.14e-3 |
Ubiquitin mediated proteolysis | 3 | UBE2C, CUL1, CDC20 | P=2.88e-3 |
TGF-beta signaling pathway | 3 | FST, TGFb3, CUL1 | P=1.60e-2 |
PPAR signaling pathway | 3 | CPT1A, PEPCK, ACSL5 | P=1.60e-6 |
Pyruvate metabolism | 3 | HAGH, PCB, PEPCK | P=1.60e-7 |
Inositol phosphate metabolism | 3 | IMPA2, INPP4A ITPKA | P=1.60e-8 |
Tryptophan metabolism | 3 | CYP1B1, MAOA, LCMT1 | P=1.60e-9 |
Pyrimidine metabolism | 3 | NME6 ,POLD3, POLR2D | P=1.60e-10 |
Citrate cycle (TCA cycle) | 2 | PC, PEPCK | P=1.60e-11 |
Fatty acid metabolism | 2 | CPT1A, ACSL5, | P=1.60e-12 |
Glutamate metabolism | 2 | GCLC, GLS | P=1.60e-13 |
Arginine and proline metabolism | 2 | ARG2, MAOA | P=1.60e-14 |
Histidine metabolism | 2 | MAOA, LCMT1 | P=1.60e-15 |
Tyrosine metabolism | 2 | MAOA, LCMT1 | P=1.60e-16 |
Selenoamino acid metabolism | 2 | SEPHS2, LCMT1 | P=1.60e-17 |
Glutathione metabolism | 2 | GCLC, MGST3 | P=1.60e-18 |
DEGs common to TSA and CBHA at 24h | |||
Cell cycle | 12 | MCM4, MCM3, MCM6 MCM7, PLK1, BUB1B, | P=1.74e-14 |
BUB1 CCNA2, CCNB2 PKMYT1 CDC6, CDC20 | |||
Glutathione metabolism | 6 | GPX7, GST4, GSTM1, GSTP1, GCLC, MGST3 | P=1.15e-8 |
Metabolism of xenobiotics by cytochrome P450 | 5 | MGST1, GST4, GSTM1, GSTP1, MGST3 | P=2.76e-6 |
Pyrimidine metabolism | 4 | POLD1, POLE2, RFC5, RRM2 | P=3.95e-4 |
Purine metabolism | 4 | POLD1, POLE2, RFC5, RRM2 | P=2.48e-3 |
DNA polymerase | 3 | POLD1, POLE2, RFC5 | P=1.20e-4 |
ECM-receptor interaction | 2 | HMMR, LAMC2 | P=3.99e-2 |
Ubiquitin mediated proteolysis | 2 | UBE2C, CDC20 | P=1.19e-2 |