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Table 4 KEGG pathways represented by DEGs commonly regulated by TSA and CBHA at 6 h or 24 h in H9c2 cells*

From: Pan-histone deacetylase inhibitors regulate signaling pathways involved in proliferative and pro-inflammatory mechanisms in H9c2 cells

DEGs common to TSA and CBHA at 6h
KEGG pathway Gene nos Entrez Gene IDs P value
MAPK signaling pathway 7 FGF7, FGF8, MKNK2, NFAT4,TGFb3, P=2.02e-3
   CD14, MAPKI8P1  
Adipocytokine signaling pathway 5 CPT1A, PEPCK, ACSL5, ADIPOR2, CAMKK1, P=9.51e-5
Purine metabolism 5 NME6, GMPR, IMPDH2, POLD3, POLR3F P=2.90e-3
Cell cycle 5 TGFb3, CUL1, CCNA2, CCNB2, CDC20 P=8.67e-4
Phosphatidylinositol signaling system 4 IMPA2, INPP4A, PIK3C2A, ITPKA P=1.14e-3
Ubiquitin mediated proteolysis 3 UBE2C, CUL1, CDC20 P=2.88e-3
TGF-beta signaling pathway 3 FST, TGFb3, CUL1 P=1.60e-2
PPAR signaling pathway 3 CPT1A, PEPCK, ACSL5 P=1.60e-6
Pyruvate metabolism 3 HAGH, PCB, PEPCK P=1.60e-7
Inositol phosphate metabolism 3 IMPA2, INPP4A ITPKA P=1.60e-8
Tryptophan metabolism 3 CYP1B1, MAOA, LCMT1 P=1.60e-9
Pyrimidine metabolism 3 NME6 ,POLD3, POLR2D P=1.60e-10
Citrate cycle (TCA cycle) 2 PC, PEPCK P=1.60e-11
Fatty acid metabolism 2 CPT1A, ACSL5, P=1.60e-12
Glutamate metabolism 2 GCLC, GLS P=1.60e-13
Arginine and proline metabolism 2 ARG2, MAOA P=1.60e-14
Histidine metabolism 2 MAOA, LCMT1 P=1.60e-15
Tyrosine metabolism 2 MAOA, LCMT1 P=1.60e-16
Selenoamino acid metabolism 2 SEPHS2, LCMT1 P=1.60e-17
Glutathione metabolism 2 GCLC, MGST3 P=1.60e-18
DEGs common to TSA and CBHA at 24h
Cell cycle 12 MCM4, MCM3, MCM6 MCM7, PLK1, BUB1B, P=1.74e-14
   BUB1 CCNA2, CCNB2 PKMYT1 CDC6, CDC20  
Glutathione metabolism 6 GPX7, GST4, GSTM1, GSTP1, GCLC, MGST3 P=1.15e-8
Metabolism of xenobiotics by cytochrome P450 5 MGST1, GST4, GSTM1, GSTP1, MGST3 P=2.76e-6
Pyrimidine metabolism 4 POLD1, POLE2, RFC5, RRM2 P=3.95e-4
Purine metabolism 4 POLD1, POLE2, RFC5, RRM2 P=2.48e-3
DNA polymerase 3 POLD1, POLE2, RFC5 P=1.20e-4
ECM-receptor interaction 2 HMMR, LAMC2 P=3.99e-2
Ubiquitin mediated proteolysis 2 UBE2C, CDC20 P=1.19e-2
  1. *The KEGG pathways associated with the common gene set affected by TSA or CBHA at 6h and 24h post-treatment in H9c2 cells are hierarchically arranged based on the number of common DEGs and the significance of enrichment (p value) derived as described in “Material and Methods”.