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Table 4 KEGG pathways represented by DEGs commonly regulated by TSA and CBHA at 6 h or 24 h in H9c2 cells*

From: Pan-histone deacetylase inhibitors regulate signaling pathways involved in proliferative and pro-inflammatory mechanisms in H9c2 cells

DEGs common to TSA and CBHA at 6h

KEGG pathway

Gene nos

Entrez Gene IDs

P value

MAPK signaling pathway

7

FGF7, FGF8, MKNK2, NFAT4,TGFb3,

P=2.02e-3

  

CD14, MAPKI8P1

 

Adipocytokine signaling pathway

5

CPT1A, PEPCK, ACSL5, ADIPOR2, CAMKK1,

P=9.51e-5

Purine metabolism

5

NME6, GMPR, IMPDH2, POLD3, POLR3F

P=2.90e-3

Cell cycle

5

TGFb3, CUL1, CCNA2, CCNB2, CDC20

P=8.67e-4

Phosphatidylinositol signaling system

4

IMPA2, INPP4A, PIK3C2A, ITPKA

P=1.14e-3

Ubiquitin mediated proteolysis

3

UBE2C, CUL1, CDC20

P=2.88e-3

TGF-beta signaling pathway

3

FST, TGFb3, CUL1

P=1.60e-2

PPAR signaling pathway

3

CPT1A, PEPCK, ACSL5

P=1.60e-6

Pyruvate metabolism

3

HAGH, PCB, PEPCK

P=1.60e-7

Inositol phosphate metabolism

3

IMPA2, INPP4A ITPKA

P=1.60e-8

Tryptophan metabolism

3

CYP1B1, MAOA, LCMT1

P=1.60e-9

Pyrimidine metabolism

3

NME6 ,POLD3, POLR2D

P=1.60e-10

Citrate cycle (TCA cycle)

2

PC, PEPCK

P=1.60e-11

Fatty acid metabolism

2

CPT1A, ACSL5,

P=1.60e-12

Glutamate metabolism

2

GCLC, GLS

P=1.60e-13

Arginine and proline metabolism

2

ARG2, MAOA

P=1.60e-14

Histidine metabolism

2

MAOA, LCMT1

P=1.60e-15

Tyrosine metabolism

2

MAOA, LCMT1

P=1.60e-16

Selenoamino acid metabolism

2

SEPHS2, LCMT1

P=1.60e-17

Glutathione metabolism

2

GCLC, MGST3

P=1.60e-18

DEGs common to TSA and CBHA at 24h

Cell cycle

12

MCM4, MCM3, MCM6 MCM7, PLK1, BUB1B,

P=1.74e-14

  

BUB1 CCNA2, CCNB2 PKMYT1 CDC6, CDC20

 

Glutathione metabolism

6

GPX7, GST4, GSTM1, GSTP1, GCLC, MGST3

P=1.15e-8

Metabolism of xenobiotics by cytochrome P450

5

MGST1, GST4, GSTM1, GSTP1, MGST3

P=2.76e-6

Pyrimidine metabolism

4

POLD1, POLE2, RFC5, RRM2

P=3.95e-4

Purine metabolism

4

POLD1, POLE2, RFC5, RRM2

P=2.48e-3

DNA polymerase

3

POLD1, POLE2, RFC5

P=1.20e-4

ECM-receptor interaction

2

HMMR, LAMC2

P=3.99e-2

Ubiquitin mediated proteolysis

2

UBE2C, CDC20

P=1.19e-2

  1. *The KEGG pathways associated with the common gene set affected by TSA or CBHA at 6h and 24h post-treatment in H9c2 cells are hierarchically arranged based on the number of common DEGs and the significance of enrichment (p value) derived as described in “Material and Methods”.