Identification of common genetic modifiers of neurodegenerative diseases from an integrative analysis of diverse genetic screens in model organisms

Chen, Xi; Burgoyne, Robert D

doi:10.1186/1471-2164-13-71

Table 1 Genetic studies for the identification of regulators of neurodegeneration models in C.elegans, S. cerevisiae and D. melanogaster

From: Identification of common genetic modifiers of neurodegenerative diseases from an integrative analysis of diverse genetic screens in model organisms

Study Number	Primary model Organism	Disease model	Expressed construct	Screen	Number of Genetic modifiers	Orthologues in C. elegans	Reference
1	C. elegans	P	Htt-Q0, Q24, Q33, Q35, and Q40	Genome-wide RNAi	186	186	[10]
2	C. elegans	SOD	G85R SOD	Genome-wide RNAi	81	81	[11]
3	C. elegans	S	WT α-synuclein	Genome-wide RNAi	82	82	[9]
4	C. elegans	T	Tau P301L and V337M	Genome-wide RNAi	75	75	[14]
5	C. elegans	S	WT α-synuclein	Hypothesis-driven RNAi	20	20	[65]
6	C. elegans	P	Htt-Q150	Candidate genes	12	12	[37]
7	C. elegans	S	WT α-synuclein	Systematic RNAi screen	11	11	[68]
8	C. elegans	P	Htt-Q128	Candidate genes	4	4	[13]
9	C. elegans	Aβ	Aβ_1-42	Candidate genes	2	2	[69]
10	C. elegans	T	Tau P301L and V337M	Forward genetic	2	2	[70]
11	C. elegans	T	Tau V337M	Candidate genes	2	2	[71]
12	C. elegans	P	Htt-Q32, Q40, Q56, Q79	Candidate genes	2	2	[72]
13	C. elegans	P	Htt-Q2 and Q150	Candidate genes	1	1	[12]
14	S. cerevisiae	P and S	Htt-Q20, Htt-Q53, A53T α-synuclein	Genome-wide genetic	138	41	[24]
15	S. cerevisiae	S	α-synuclein	Selected genetic screen	77	20	[73]
16	S. cerevisiae	Aβ	Aβ1-42	Genome-wide genetic	40	11	[60]
17	S. cerevisiae	P	Htt-Q103	Genome-wide loss-of-function suppressor	30	5	[50]
18	S. cerevisiae	S	WT α-synuclein	Genome-wide overexpression	22	7	[58]
19	S. cerevisiae	S	WT α-synuclein	Candidate genes	5	1	[59]
20	D. melanogaster	T	Tau V337M	Large-scale genetic	30	14	[74]
21	D. melanogaster	P	Htt-Q128	protein interaction and selected genetic screen	32	34	[75]
22	D. melanogaster	P	SCA1 82Q and Htt-Q128	Selective genetic modifier screen	24	20	[34]
23	D. melanogaster	T	Tau V337M	Large-scale genetic	24	10	[76]
24	D. melanogaster	P	Htt-Q127	Selective genetic modifier screen	10	2	[77]
25	D. melanogaster	P	SCA3trQ78	Genome-wide screen	18	17	[63]
26	D. melanogaster	P	SCA1 30Q and 82Q	Large-scale genetic	17	11	[78]
27	D. melanogaster	P	Htt-Q127	Genome-wide screen	2	1	[79]
28	D. melanogaster	S	A30P and A53T α-synuclein	Candidate gene	1	1	[80]
Total					950	675

The number of regulators of neurodegeneration that were identified in each study is shown along with the number of these genes with orthologues in C elegans. The disease models include organisms expressing forms of β-amyloid (AB), polyQ expansions (P), wild type or mutant α-synuclein (S), mutant superoxide dismutase (SOD), or mutant tau (T).

Back to article page

ISSN: 1471-2164

Contact us

Submission enquiries: bmcgenomics@biomedcentral.com
General enquiries: ORSupport@springernature.com

BMC Genomics

Contact us