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Table 2 Overlapping genetic regulators of neurodegeneration with orthologues in C.elegans

From: Identification of common genetic modifiers of neurodegenerative diseases from an integrative analysis of diverse genetic screens in model organisms

Sequence Name

Gene name

Description

Organism

Disease model

Expression in neurons

Y53C10A.12

hsf-1

Heat-shock transcription factor

worm

Aβ, P, S, SOD, T

yes

F26D10.3

hsp-1

HSP70 protein family

fly, worm

P, T, S

yes

F54D5.8

dnj-13

Molecular chaperone (DnaJ)

fly

P, T

?

K01C8.10

cct-4

Chaperone containing TCP-1

worm

P, SOD

yes

C07G2.3

cct-5

Chaperone containing TCP-1

worm

P, SOD

?

T09B4.10

chn-1

C-term of HSP-70 interacting protein (E3 ubiquitin ligase)

fly, worm

P, T

yes

Y94H6A.6

ubc-8

Ubiquitin conjugating enzyme

fly, yeast

P, S

?

M7.1

let-70

E2 Ubiquitin conjugating enzyme

fly

P

yes

C06A1.1

cdc-48.1

AAA ATPase, functions as a ubiquitin-related chaperone

worm

P

Yes

F52D10.3, M117.2

ftt-2, par-5

14-3-3 family

fly

P

yes

C39F7.4

rab-1

Small Ras-like GTPase Rab1

fly, yeast, worm

P, S

yes

B0361.10

ykt-6

SNARE protein YKT6

yeast

S

?

C54H2.5

sft-4

SURF-4 related to cargo transport protein ERV29

worm, yeast

S

yes

Y54E2A.12

tbc-20

Predicted GTPase activator protein

yeast

S

?

R11A8.4

sir-2.1

NAD-dependent histone deacetylase

fly, worm

P, S

Yes

C53A5.3

hda-1

Histone deacetylase 1

fly, worm

P, S

No?

F02E9.4

sin-3

SIN3 family of histone deacetylase subunits

fly

P, S

yes

F59F4.1

-

Acyl-CoA oxidase

fly, yeast, worm

P, S, T

?

ZK256.1a

pmr-1

Golgi P-type ATPase Ca2+ -pump

yeast

S

yes

W08D2.5,

catp-6

Predicted lysosomal P-type ATPase

worm, yeast

S

?

Y43F4B.4

npp-18

Nuclear pore complex protein

fly

P

yes

F49E10.5

ctbp-1

Transcriptional co-repressor homolog

fly

P

?

K08F8.6

let-19

Transcriptional cofactor

fly

P

yes

T17E9.1

kin-18

Serine-threonine protein kinase

fly, worm

P, T

yes

H18N23.2

-

Protein phosphatase, regulatory subunit PPP1R3C/D

fly, worm

P, SOD

?

T14F9.1

vha-15 (phi-52)

Vacuolar ATPase subunit H

worm

P, S

Yes

T21E12.4

dhc-1

Dynein heavy chain

fly, worm

P

Yes

Y113G7B.18

mdt-17

MeDiaTor

worm

S, SOD

?

Y116A8C.35

uaf-2

U2AF splicing factor

worm

P, S

Yes

F56C11.1

bli-3

Homologue of dual oxidase

worm

P, SOD

No

C32E8.10c

unc-11

Clathrin-adaptor protein AP180

worm, yeast

Aβ, P

Yes

JC8.10b

unc-26

Synaptojanin

worm, yeast

Aβ, P

Yes

ZK742.1a

xpo-1

Exportin-1

Fly, yeast

Aβ, P

?

C05C8.7

phi-49

Mannose-6-phosphate isomerase

worm

P, SOD

No

  1. The genes were included if they were identified in more than one genetic screen. The disease models included organisms expressing forms of β-amyloid (AB), polyQ expansions (P), wild type or mutant α-synuclein (S), mutant superoxide dismutase (SOD), or mutant tau (T). Under expression in neurons a question mark indicates that no data are available in Wormbase.