Figure 1

DA and DA.F344(Cia5a) rats differ in arthritis severity and have different synovial gene expression profiles. (A) Map of the Cia5a locus on rat chromosome 10, and the congenic interval boundaries (black=homozygous for F344 alleles; white=homozygous for DA alleles; grey=recombination interval). (B) DA rats had severe disease at 21 days post-induction of PIA; DA.F344(Cia5a) congenics were protected and developed a significantly milder form of arthritis (p=0.002, Mann–Whitney test; boxes show the median and 25%-75% percentiles). (C) 7,925 genes were expressed in all synovial tissues. 2,648 (33.4%) met the 1.5-fold difference and p-value of ≤0.01 (t-test) for significant difference. 134 genes differed by ≥5-fold and less <10-fold, and 46 genes differed by ≥10-fold (inset).