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Table 4 Members of the Syk kinase pathway up-regulated in DA synovium compared with down-regulation in DA.F344(Cia5a)

From: The arthritis severity locus Cia5a regulates the expression of inflammatory mediators including Syk pathway genes and proteases in pristane-induced arthritis

Gene Symbol

Gene Name

Entrez Gene ID

Fold DA/Cia5a

p-value*

Activating receptors

    

Fcer1g

Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide

25441

2.50

0.0004

Fcgr2a

Fc fragment of IgG, low affinity IIa, receptor (CD32)

116591

3.08

0.005

Tcrg

T cell receptor gamma locus

24821

3.32

0.0001

Trem2

triggering receptor expressed on myeloid cells 2

301227

2.69

0.0006

Tyrobp

Tyro protein tyrosine kinase binding protein

361537

4.80

0.0001

Integrins

    

Itgam

integrin alpha M

25021

3.58

0.0001

Itgav

integrin alpha V

296456

1.61

0.0004

Itga5

integrin alpha 5 (fibronectin receptor alpha)

315346

3.47

0.00000001

Itgb2

integrin beta 2

309684

3.44

0.0001

Itgb7

integrin, beta 7

25713

3.86

0.002

c-type lectin receptors

    

Clec4a1

C-type lectin domain family 4, member a1, Dcir4

362430

2.38

0.001

Clec4a3

C-type lectin domain family 4, member a3, Dcir3

362431

3.00

0.0004

Clec7a

C-type lectin domain family 7, member a, Dectin 1

502902

8.48

0.001

Clec11a

C-type lectin domain family 11, member a, Scgf

29313

4.24

0.00000008

 

Syk and Syk-binding and intermediate partners

Ezr**

ezrin

54319

2.42

0.0001

Lat

linker for activation of T cells

81511

3.83

0.000001

Lcp2

lymphocyte cytosolic protein 2

155918

2.02

0.007

Ptk2b

PTK2B protein tyrosine kinase 2 beta

50646

2.54

0.0000002

RhoG

ras homolog gene family, member G (rho G)

308875

1.54

0.0008

RhoH

ras homolog gene family, member H

305341

2.25

0.001

Syk

spleen tyrosine kinase

25155

5.43

0.00004

Vav1

vav 1 guanine nucleotide exchange factor

25156

4.60

0.0001

NFκB genes and pathway

    

Ikbkb

inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta

84351

1.60

0.0006

Ikbke

inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon

363984

1.64

0.0001

Nfkb1

nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

81736

1.88

0.002

Nfkb2

nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100

309452

1.98

0.00003

 

Cytokine and chemokine transcription§

Ccl2

chemokine (C-C motif) ligand 2

24770

3.95

0.01

Ccl7

chemokine (C-C motif) ligand 7

287561

7.90

0.002

Il1b

interleukin 1 beta

24494

5.17

0.002

Ltb

lymphotoxin beta (TNF superfamily, member 3)

361795

3.77

0.0002

Cell Proliferation

    

Cdc2

cell division cycle 2, G1 to S and G2 to M

54237

24.16

0.00002

Ccnb2

cyclin B2

363088

22.95

0.000005

Cks2

CDC28 protein kinase regulatory subunit 2

498709

11.62

0.000006

Prc1

protein regulator of cytokinesis 1

308761

13.08

0.00002

Spc24

SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)

363028

14.72

0.000002

Cytoskeletal changes

    

Actr3

ARP3 actin-related protein 3 homolog (yeast)

81732

1.88

0.0001

Arpc4

actin related protein 2/3 complex, subunit 4

297518

1.61

0.00005

Capzb

capping protein (actin filament) muscle Z-line, beta

298584

1.64

0.0003

Coro1b

coronin, actin-binding protein, 1B

29474

1.68

0.0001

Myo9b

myosin IXb

25486

1.93

0.00003

Tiam2

T-cell lymphoma invasion and metastasis 2

308142

2.61

0.00003

Parva

parvin, alpha

57341

2.19

0.00005

 

Reactive oxygen species production

Cyba

cytochrome b-245, alpha polypeptide

79129

2.72

0.00001

Ncf1

neutrophil cytosolic factor 1

114553

6.00

0.0001

Ncf2

neutrophil cytosolic factor 2

364018

4.75

0.0003

Ncf4

neutrophil cytosolic factor 4

500904

2.46

0.004

Rac2¶

ras-related C3 botulinum toxin substrate 2 (small GTP binding protein Rac2)

366957

2.32

0.0007

  1. Syk gene is underlined. * t-test;
  2. §=All four chemokine and cytokine listed genes are NFkB-inducible targets.
  3. ** Ezrin is also involved in cytoskeleton regulation.
  4. ¶ Rac also regulates NFkB activity, cytoskeleton and cell proliferation.
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BMC Genomics

ISSN: 1471-2164

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