The arthritis severity locus Cia5a regulates the expression of inflammatory mediators including Syk pathway genes and proteases in pristane-induced arthritis

Table 5 Anti-inflammatory genes and nuclear receptors up-regulated in DA.F344(Cia5a) congenics

Gene Symbol	Gene Name	Entrez Gene ID	Fold difference DA/Cia5a	p-value*
	*Anti-inflammatory and regulators of immune responses*
Scd1	stearoyl-Coenzyme A desaturase 1	246074	54.62	0.0001
Timp3	TIMP metallopeptidase inhibitor 3	25358	11.48	0.000000003
Adipoq	adiponectin, C1Q and collagen domain containing	246253	10.96	0.000003
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	25622	4.18	0.00002
Cyp2j3	cytochrome P450, family 2, subfamily j, polypeptide 3	313375	3.38	0.002
Ptgis	prostaglandin I2 (prostacyclin) synthase	25527	2.63	0.0003
Cat	catalase	24248	1.91	0.002
Gss	glutathione synthetase	25458	1.56	0.001
Sod1	superoxide dismutase 1, soluble	24786	1.53	0.00002
	*Nuclear receptors and an interacting protein*
Rxrg	retinoid X receptor gamma, Nr2b3	83574	5.39	0.0001
Pparg	peroxisome proliferator-activated receptor gamma, Nr1c3	25664	5.32	0.00005
Rev-erba	Nr1d1	252917	3.41	0.004
Arp1	Nr2f2	113984	2.45	0.0002
Nrip1	nuclear receptor interacting protein 1	304157	2.35	0.00004
Thrb	thyroid hormone receptor beta, Nr1a2	24831	2.07	0.002
Thra	thyroid hormone receptor alpha, Nr1a1	81812	1.97	0.001
Ncor1	nuclear receptor co-repressor 1	54299	1.89	0.003
Rora	RAR-related orphan receptor alpha, Nr1f1	300807	1.88	0.0001
Lxra	Liver X receptor alpha, Nr1h3	58852	1.52	0.0006

ISSN: 1471-2164