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Table 3 Abundance and tissue specificity of human known miRNAs’ expression

From: Evolutionary relationships between miRNA genes and their activity

Samples Younga Middlea Olda P value (Young,Middle) P value (Young,Old) P value (Middle,Old)
Tissue specificity score (median) All 2.59 1.41 0.95 4.9e-13 3.2e-16 0.0002
  Normal 3.32 2.07 1.32 7.1e-12 2.2e-16 1.6e-05
  Malignant 2.42 1.76 1.28 0.0002 2.9e-07 0.0021
  P value (Normal,Malignant) 0.0003 0.032 0.8184 - - -
Maximum expression level (median) All 0.0019 0.0075 0.0271 1.5e-09 2.2e-16 8.7e-11
  Normal 0.0017 0.0033 0.0116 0.0007 2.7e-14 9.4e-10
  Malignant 0.0020 0.0067 0.0269 2.3e-08 9.7e-14 4.1e-08
  P value (Normal,Malignant) 0.4786 0.0001 0.0042 - - -
  1. a The eight age groups were integrated into three as small number of newly birthed miRNAs has expression data, on which statistical analysis is likely to be spurious. Those miRNAs originated after the primate-rodent split was grouped into a group, referred as Young; those originated after rodent-non-mammalian split and before the primate-rodent split was grouped into Middle, and those originated before cow was grouped into Old. Wilcoxon statistics were used to test significances.