Figure 1

Integrative network view of antiestrogen resistant breast cancer cells. Expression patterns of the network were depicted in (a) MCF7-T over MCF7 and (b) MCF7-F over MCF7. The TFs, the signaling proteins, and the miRNA target genes were functionally involved in “hallmarks of the cancer” suggested by Hanahan and Weinburg [24]. The hexagon denotes miRNA target mRNAs (from miRTarBase), protein-coding genes corresponding to TFs (from TransmiR), and signaling proteins (from TransmiR). The triangle denotes the miRNAs, and the rectangle the cancer contexts. The number of connections in a node corresponds to the node size. The blunt-ended solid edge in blue represents miRNA-mediated target mRNA inhibition. The circle-ended dashed edge in black represents a TF binding to the miRNA promoter, or denotes an upstream signaling protein regulating the miRNA. The grey solid edge indicates association between the cancer contexts and the protein coding genes (including miRNA target mRNAs). The fold change color scale bar is represented in the bottom. Far left values (minimum) and far right values (maximum) in the scale bar are 0.039 and 12.4 for MCF7-F/MCF7, and 0.083 and 5.3 for MCF7-T/MCF7.