Altered gene expression profiles in the hippocampus and prefrontal cortex of type 2 diabetic rats

BMC Genomics

Table 1 Number of genes with significant expression changes in specific brain areas of diabetes models vs. control rats.

	Type 2 diabetes model			Type 1 diabetes model
	Hipp	Pfc	Str	Hipp	Pfc	Str
Statistical analysis	504	232	3	7	0	0
Post-screening	266	147	3	0	0	0
Genes in significant pathways	64	36	0	0	0	0
Genes to be validated*	42	27	0	0	0	0
Validated genes	30	22	0	0	0	0

The table represents significant genes remaining following each stage of the normalization-evaluation procedure. For details, see Methods and Results sections. Abbreviations used: Hipp: hippocampus; Pfc: prefrontal cortex; Str: striatum.
* Reduction was due to technical criteria of the TaqMan RT-PCR system (only genes with commercially available TaqMan probes could be validated).

ISSN: 1471-2164