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Table 1 Number of genes with significant expression changes in specific brain areas of diabetes models vs. control rats.

From: Altered gene expression profiles in the hippocampus and prefrontal cortex of type 2 diabetic rats

  Type 2 diabetes model Type 1 diabetes model
  Hipp Pfc Str Hipp Pfc Str
Statistical analysis 504 232 3 7 0 0
Post-screening 266 147 3 0 0 0
Genes in significant pathways 64 36 0 0 0 0
Genes to be validated* 42 27 0 0 0 0
Validated genes 30 22 0 0 0 0
  1. The table represents significant genes remaining following each stage of the normalization-evaluation procedure. For details, see Methods and Results sections. Abbreviations used: Hipp: hippocampus; Pfc: prefrontal cortex; Str: striatum.
  2. * Reduction was due to technical criteria of the TaqMan RT-PCR system (only genes with commercially available TaqMan probes could be validated).