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Table 2 Effect of a chronic Western diet on the expression of genes related to cholesterol and lipid metabolism in the small intestine a

From: C57Bl/6 N mice on a western diet display reduced intestinal and hepatic cholesterol levels despite a plasma hypercholesterolemia

Symbol Gene name FC q-value
Abca1 ATP-binding cassette, sub-family A, 1 -1.13 0.466
Abcg5 ATP-binding cassette, sub-family G, 5 -1.48 0.006
Abcg8 ATP-binding cassette, sub-family G, 8 -2.35 0.002
Acaa2 acetyl-Coenzyme A acyltransferase 2 1.67 0.010
Apoa2 Apolipoprotein A-II 3.15 0.001
Apoc2 Apolipoprotein C-II 1.36 0.006
Cav1 Caveolin 1 1.6 0.006
CD36 CD36 antigen 2.11 0.020
Ces1d Carboxylesterase 1D -6.13 < 0.001
Ces1g Carboxylesterase 1G -5.46 < 0.001
Cpt1a Carnitine palmitoyltransferase 1a, liver 1.55 0.044
Cyp27a1 Cytochrome P450, family 27, subfamily a, polypeptide 1 -2.57 0.004
Cyp51 Cytochrome P450, family 51 2.03 0.001
Dhcr7 7-dehydrocholesterol reductase 1.48 0.011
Hmgcl 3-hydroxy-3-methylglutaryl-Coenzyme A lyase 1.57 0.024
Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase 1.02 0.748
Hmgcs2 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 8.07 < 0.001
Hsd17b7 Hydroxysteroid (17-beta) dehydrogenase 7 1.32 0.045
Idh1 Isocitrate dehydrogenase 1 (NADP+), soluble 1.31 0.010
LDLr LDL receptor 4.29 < 0.001
LXRα Liver × receptor alpha 1.77 0.003
LXRβ Liver × receptor beta -1.06 0.646
Me1 Malic enzyme 1, NADP(+)-dependent, cytosolic 3.13 < 0.001
Mttp Microsomal triglyceride transfer protein 1.18 0.016
Mvd Mevalonate decarboxylase 1.33 0.012
Mvk Mevalonate kinase 1.22 0.017
Npc1l1 Niemann-Pick C1-like protein 1 -2.02 < 0.001
Nsdhl NAD(P) dependent steroid dehydrogenase-like 1.45 0.004
Pcsk9 Proprotein convertase subtilisin/kexin type 9 1.65 0.007
Pmvk Phosphomevalonate kinase 2.46 < 0.001
Scarb1 Scavenger receptor class B, member 1 1.4 0.447
Scd1 Stearoyl-Coenzyme A desaturase 1 90.7 < 0.001
Scd2 Stearoyl-Coenzyme A desaturase 2 6.50 < 0.001
Slc25a1 Solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1 2.04 < 0.001
Slc27a4 solute carrier family 27 (fatty acid transporter), member 4 -1.12 0.209
Sqle Squalene epoxidase 2.11 0.011
Srebp-2 Sterol regulatory element binding factor 2 1.59 0.004
Tm7sf2 Transmembrane 7 superfamily member 2 1.52 0.003
  1. aAbbreviations: FC fold change (Western diet vs. control).