Figure 4

Overlap between 239 conserved modifiers of 128Q-neuron dysfunction in C-elegans and genes dysregulated in the striatum of either CHL2 knock-in mice or R6/2 transgenic mice. (A) Overlap between dysregulated genes in the mouse striatum and suppressors of 128Q-neuron dysfunction that have mouse orthologs. Numbers of genes are indicated. The lists of genes at the intersection of the nematode and mouse datasets are indicated below the graphs. (B) Overlap between dysregulated genes in the mouse striatum and enhancers of 128Q-neuron dysfunction that have mouse orthologs. The numbers of genes is indicated. The lists of genes at the intersection of the nematode and mouse datasets are indicated below the graphs. Some genes are oppositely dysregulated in the CHL2 mice compared to R6/2 mice (yellow tags). In all panels, red circles indicate C. elegans genes that modify 128Q-neuron toxicity. *Druggable genes.