A study on promoter characteristics of head-to-head genes in Saccharomyces cerevisiae

BMC Genomics

Table 2 Association of adjacent genes in terms of number of TFs that bind/regulate both genes

		#pair			Co-expression			Functional association
#TF		H2h	H2t	T2t	H2h	H2t	T2t	H2h	H2t	T2t
TFs with binding evidence to both genes
	0 TF	405	1,761	1,229	0.229	0.221	0.245	1.839	1.641	1.690
	1 TF	301	595	240	0.256	0.215	0.246	1.736	1.727	1.638
	2 TFs	271	246	105	0.246	0.229	0.268	1.779	1.724	1.724
	3 TFs	158	113	-	0.261	0.252	-	1.663	1.753	-
	4 TFs	117	141	-	0.268	0.279	-	1.560	1.971	-
	5 TFs	252	-	-	0.276	-	-	1.863	-	-
	PCC				0.911	0.918	0.899	-0.247	0.877	0.396
TFs with regulation evidence to both genes
	0 TF	1,053	2,098	1,212	0.232	0.212	0.237	1.673	1.572	1.644
	1 TF	299	522	265	0.260	0.226	0.269	1.885	1.854	1.660
	2 TFs	152	236	97	0.329	0.299	0.287	2.021	2.027	2.148
	PCC				0.972	0.931	0.986	0.992	0.991	0.880
Overall		1,504	2,856	1,574

Values highlighted with bold font indicate using more than and equal to the number of TFs for sufficient pairs. For example, number of h2h pairs with four TFs with binding evidence is 117; while number of h2t pair with ≥4 TFs with binding evidence is 141. Higher co-expression or functional association indicates better gene association; see the Methods section for the details.

ISSN: 1471-2164