Skip to main content

Table 2 Association of adjacent genes in terms of number of TFs that bind/regulate both genes

From: A study on promoter characteristics of head-to-head genes in Saccharomyces cerevisiae

  #pair Co-expression Functional association
#TF   H2h H2t T2t H2h H2t T2t H2h H2t T2t
TFs with binding evidence to both genes
  0 TF 405 1,761 1,229 0.229 0.221 0.245 1.839 1.641 1.690
  1 TF 301 595 240 0.256 0.215 0.246 1.736 1.727 1.638
  2 TFs 271 246 105 0.246 0.229 0.268 1.779 1.724 1.724
  3 TFs 158 113 - 0.261 0.252 - 1.663 1.753 -
  4 TFs 117 141 - 0.268 0.279 - 1.560 1.971 -
  5 TFs 252 - - 0.276 - - 1.863 - -
  PCC     0.911 0.918 0.899 -0.247 0.877 0.396
TFs with regulation evidence to both genes
  0 TF 1,053 2,098 1,212 0.232 0.212 0.237 1.673 1.572 1.644
  1 TF 299 522 265 0.260 0.226 0.269 1.885 1.854 1.660
  2 TFs 152 236 97 0.329 0.299 0.287 2.021 2.027 2.148
  PCC     0.972 0.931 0.986 0.992 0.991 0.880
Overall   1,504 2,856 1,574       
  1. Values highlighted with bold font indicate using more than and equal to the number of TFs for sufficient pairs. For example, number of h2h pairs with four TFs with binding evidence is 117; while number of h2t pair with ≥4 TFs with binding evidence is 141. Higher co-expression or functional association indicates better gene association; see the Methods section for the details.