Prioritization of pathogenic mutations in the protein kinase superfamily

BMC Genomics

Table 2 Number of mutations in each of the groups in which UniProt divides the protein kinase superfamily

Group	Disease	Neutral	Total
TK †	496	565	1061
TKL †	172	151	323
Atypical_PI3-PI4 †	49	138	187
CAMK †	40	518	558
Other	36	411	447
RGC †	23	35	58
CMGC †	18	178	196
AGC †	16	190	206
STE	7	222	229
Atypical_ADCK	6	14	20
Atypical_Alpha-type	1	88	89
CK1	1	52	53
NEK	0	45	45
Atypical_RIO	0	14	14
Atypical_PDK-BCKDK	0	5	5
Atypical_FAST	0	1	1

Number of mutations in each of the groups in which UniProt divides the protein kinase superfamily. The groups enriched in disease-associated mutations are highlighted by †.

ISSN: 1471-2164