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Table 4 Performance for optimizing the combination of three drugs in the presence of noise.

From: Adaptive reference update (ARU) algorithm. A stochastic search algorithm for efficient optimization of multi-drug cocktails

  Noise level Search type Performance metric Gur Game (simultaneous) Gur Game (sequential) Previous search algorithm[11](α= 1) ARU algorithm (proposed) (α= 1)
f3a(x) (2%) A success rate unique comb. 1% 3% 99% 100%
     2.4 7.3 110.6 77.3
   B success rate iterations 1% 3% 99% 100%
     2.8 10.9 201.1 139.6
  (5%) A success rate unique comb. 1% 3% 99% 100%
     2.4 7.4 111.7 78.4
   B success rate iterations 1% 3% 99% 100%
     2.5 10.1 201.6 144.0
  (8%) A success rate unique comb. 1% 3% 99% 100%
     2.5 7.7 113.3 80.5
   B success rate iterations 1% 3% 99% 100%
     2.3 9.4 210.9 151.7
f3b(x) (2%) A success rate unique comb. 86% 69% 99% 99%
     224.3 201.6 110.8 93.3
   B success rate iterations 83% 59% 99% 99%
     367.1 419.1 211.5 205.3
  (5%) A success rate unique comb. 89% 72% 99% 99%
     222.3 201.6 116.6 106.2
   B success rate iterations 83% 59% 98% 98%
     359.3 439.9 225.5 222.9
  (8%) A success rate unique comb. 90% 74% 97% 98%
     225.9 200.9 126.4 114.3
   B success rate iterations 82% 60% 97% 98%
     359.4 431.3 249.1 246.8