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Table 4 Performance for optimizing the combination of three drugs in the presence of noise.

From: Adaptive reference update (ARU) algorithm. A stochastic search algorithm for efficient optimization of multi-drug cocktails

 

Noise level

Search type

Performance metric

Gur Game (simultaneous)

Gur Game (sequential)

Previous search algorithm[11](α= 1)

ARU algorithm (proposed) (α= 1)

f3a(x)

(2%)

A

success rate unique comb.

1%

3%

99%

100%

    

2.4

7.3

110.6

77.3

  

B

success rate iterations

1%

3%

99%

100%

    

2.8

10.9

201.1

139.6

 

(5%)

A

success rate unique comb.

1%

3%

99%

100%

    

2.4

7.4

111.7

78.4

  

B

success rate iterations

1%

3%

99%

100%

    

2.5

10.1

201.6

144.0

 

(8%)

A

success rate unique comb.

1%

3%

99%

100%

    

2.5

7.7

113.3

80.5

  

B

success rate iterations

1%

3%

99%

100%

    

2.3

9.4

210.9

151.7

f3b(x)

(2%)

A

success rate unique comb.

86%

69%

99%

99%

    

224.3

201.6

110.8

93.3

  

B

success rate iterations

83%

59%

99%

99%

    

367.1

419.1

211.5

205.3

 

(5%)

A

success rate unique comb.

89%

72%

99%

99%

    

222.3

201.6

116.6

106.2

  

B

success rate iterations

83%

59%

98%

98%

    

359.3

439.9

225.5

222.9

 

(8%)

A

success rate unique comb.

90%

74%

97%

98%

    

225.9

200.9

126.4

114.3

  

B

success rate iterations

82%

60%

97%

98%

    

359.4

431.3

249.1

246.8