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Table 5 Performance for optimizing the combination of four drugs in the presence of noise.

From: Adaptive reference update (ARU) algorithm. A stochastic search algorithm for efficient optimization of multi-drug cocktails

  Noise level Search type Performance metric Gur Game (simultaneous) Gur Game (sequential) Previous search algorithm[11](α= 1) ARU algorithm (proposed) (α= 1)
f4a(x) (2%) A success rate unique comb. 21% 13% 96% 98%
     798.9 711.7 393.9 327.4
   B success rate iterations 21% 12% 96% 97%
     941.9 1032.1 558.3 452.3
  (5%) A success rate unique comb. 21% 14% 90% 95%
     816.3 653.6 473.1 398.3
   B success rate iterations 21% 13% 90% 95%
     895.6 1022.9 675.4 581.2
  (8%) A success rate unique comb. 24% 14% 85% 95%
     858.7 681.6 505.7 433.6
   B success rate iterations 23% 13% 84% 92%
     997.1 1008.9 720.8 648.5
f4b(x) (2%) A success rate unique comb. 62% 41% 100% 100%
     634.5 523.1 138.0 103.1
   B success rate iterations 51% 26% 100% 100%
     932.4 903.0 236.9 182.8
  (5%) A success rate unique comb. 75% 68% 100% 100%
     610..2 468.0 231.1 150.9
   B success rate iterations 50% 25% 100% 100%
     855.9 921.2 411.0 258.8
  (8%) A success rate unique comb. 86% 82% 98% 100%
     525.8 430.1 314.2 215.9
   B success rate iterations 50% 24% 94% 100%
     835.3 979.2 602.0 393.8