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Table 7 Performance for optimizing the combination of six drugs in the presence of noise.

From: Adaptive reference update (ARU) algorithm. A stochastic search algorithm for efficient optimization of multi-drug cocktails

  Noise level Search type Performance metric Gur Game (simultaneous) Gur Game (sequential) Previous search algorithm[11](α= 1) ARU algorithm (proposed) (α= 1)
f6a(x) (2%) A success rate unique comb. 91% 43% 100% 100%
     1280.0 1214.1 476.8 432.6
   B success rate iterations 90% 43% 100% 100%
     1352.6 1662.6 531.4 503.6
  (5%) A success rate unique comb. 90% 44% 99% 99%
     1262.3 1247.2 621.0 598.3
   B success rate iterations 90% 45% 100% 100%
     1396.8 1675.9 763.7 736.1
  (8%) A success rate unique comb. 90% 46% 98% 98%
     1204.7 1302.4 723.2 698.8
   B success rate iterations 90% 46% 98% 98%
     1412.2 1681.9 875.2 834.3
f6b(x) (2%) A success rate unique comb. 91% 43% 100% 100%
     509.9 971.0 341.4 237.7
   B success rate iterations 94% 44% 100% 100%
     1240.7 1646.0 436.5 293.5
  (5%) A success rate unique comb. 90% 42% 100% 100%
     473.8 970.7 349.9 279.8
   B success rate iterations 94% 44% 100% 100%
     1278.6 1704.9 480.8 324.6
  (8%) A success rate unique comb. 89% 42% 100% 100%
     454.4 969.9 457.4 353.2
   B success rate iterations 94% 44% 100% 100%
     1333.1 1775.5 545.3 391.5