Table 2 Curation of drug-protein relations from Pub-Med abstracts
Relation | Protein | Drug | PMID | Relation Proof |
|---|---|---|---|---|
Up-Regulated | BRCA1 | Estradiol | 7553629 | "BRCA1 mRNA and protein levels were significantly decreased in estrogen-depleted MCF-7 and BT20T cells and increased again after stimulation with beta-estradiol". |
Down-Regulated | P53 | Cycloheximide | 9484835 | "Treatment of cells with cycloheximide (CHX) prevented the activation of p53 in all phases of the cell cycle and its accumulation in G1/S and S". |
Indirect | BRCA1 | Hydroxyurea | 9267023 | "Hydroxyurea-mediated DNA synthesis arrest of S phase MCF7 cells led to a loss of BRCA1 from these structures". |
Ambiguous | GCR | Dexamethasone | 12974633 | "GRalpha and GRbeta transcripts are coordinately upregulated in CEM-C7 cells and coordinately downregulated in IM-9 cells by dexamethasone". |
Unknown | AKT1 | Phosphothreonine | 11087733 | The drug-protein relation is not mentioned in the text. |