Figure 3

Temporal profiles of cell densities of M1 (red line), M2 (blue line), and the total macrophage (black line) in LV 28 days post-MI. Computational results were normalized to initial conditions and shown in solid lines. The initial cells number of unactivated macrophage is 2 × 10³ cells/ml. The differentiated rate from monocytes to M1 macrophages α is 0.5. Then, the initial condition of macrophage densities were chosen as M 1(0) = M 2(0) = 0 cells/ml. Previously published experimental results were normalized to the corresponding measurements in control group and are shown as black crosses collected from C57 adult mice at days 1, 3, 5, 7, 14, 21, 28 [35]. Values are mean ± SE. All experiments were carried out in mice with MI.