Table 2 Statistical results for modulator-TF-target Interaction
From: A modulator based regulatory network for ERα signaling pathway
ERα genomic | ERα non-genomic | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Classification | a2 | b1 | b2 | # of unique M/T | # of connection | FDR (%) | # of unique M/T | # of connection | FDR (%) | |
1 | TF (Ind. Activator) | 0 | + | 0 | - | - | - | - | - | - |
2 | TF (Ind. Repressor) | 0 | - | 0 | - | - | - | - | - | - |
3 | TF (Ind. Activator) and M (Ind. Activator) | + | + | 0 | 58/21 | 67 | 34.870 | 367/2590 | 6447 | 1.906 |
4 | TF (Ind. Repressor) and M (Ind. Activator) | + | - | 0 | 0/0 | 0 | NA | 0/0 | 0 | NA |
5 | TF (Ind. Activator) and M (Ind. Repressor) | - | + | 0 | 36/14 | 40 | 16.688 | 306/1035 | 3230 | ~ 0 |
6 | TF (Ind. Repressor) and M (Ind. Repressor) | - | - | 0 | 0/0 | 0 | NA | 144/88 | 349 | ~ 0 |
7 | TF (Activator) and M (Agonist) | 0 | + | + | 185/21 | 307 | 14.133 | 419/2372 | 71465 | 0.587 |
8 | TF (Activator) and M (Antagonist) | 0 | + | - | 282/47 | 908 | 3.676 | 470/4875 | 71166 | 0.824 |
9 | TF (Repressor) and M (Antagonist) | 0 | - | + | 94/2 | 96 | 0 | 258/206 | 5125 | 1.289 |
10 | TF (Repressor) and M (Agonist) | 0 | - | - | 0/0 | 0 | NA | 0/0 | 0 | NA |
11 | TF (Activator) and M (Agonist & Ind. Activator) | + | + | + | 0/0 | 0 | NA | 0/0 | 0 | NA |
12 | TF (Activator) and M (Antagonist & Ind. Activator) | + | + | - | 284/51 | 849 | 1.572 | 477/5204 | 78213 | 0.206 |
13 | TF (Repressor) and M (Antagonist & Ind. Activator) | + | - | + | 0/0 | 0 | NA | 0/0 | 0 | NA |
14 | TF (Repressor) and M (Agonist & Ind. Activator) | + | - | - | 0/0 | 0 | NA | 0/0 | 0 | NA |
15 | TF (Activator) and M (Agonist & Ind. Repressor) | - | + | + | 272/22 | 934 | 1.072 | 432/2171 | 51064 | 0.244 |
16 | TF (Activator) and M (Antagonist & Ind. Repressor) | - | + | - | 0/0 | 0 | NA | 0/0 | 0 | NA |
17 | TF (Repressor) and M (Antagonist & Ind. Repressor) | - | - | + | 23/2 | 26 | 12.837 | 332/442 | 8152 | ~ 0 |
18 | TF (Repressor) and M (Agonist & Ind. Repressor) | - | - | - | 0/0 | 0 | NA | 0/0 | 0 | NA |
19 | M (Ind. Activator) | + | 0 | 0 | - | - | - | - | - | - |
20 | M (Ind. Repressor) | - | 0 | 0 | - | - | - | - | - | - |
21 | M (Activator Agonist) | 0 | 0 | + | 261/37 | 835 | 4.797 | 418/3619 | 118241 | 0.479 |
22 | M (Repressor Agonist) | 0 | 0 | - | 42/8 | 65 | 15.404 | 213/977 | 5546 | 1.709 |
23 | M (Activator Agonist & Ind. Activator) | + | 0 | + | 0/0 | 0 | NA | 0/0 | 0 | NA |
24 | M (Repressor Agonist & Ind. Activator) | + | 0 | - | 23/9 | 34 | 19.633 | 354/1453 | 6119 | 0.951 |
25 | M (Activator Agonist & Ind. Repressor) | - | 0 | + | 277/40 | 638 | 2.093 | 440/3852 | 80644 | 0.336 |
26 | M (Repressor Agonist & Ind. Repressor) | - | 0 | - | 0/0 | 0 | NA | 0/0 | 0 | NA |
27 | No Function | 0 | 0 | 0 | - | - | - | - | - | - |