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Table 4 The disease association of iLOCi selected genes from gene-only SNP analyses

From: iLOCi: a SNP interaction prioritization technique for detecting epistasis in genome-wide association studies

Disease # iLOCi genes in top 1000 SNP pairs Reported in WTCCC
single SNP analyses
Reported in HuGE Navigator database
   # Analyzed genes
(# SNPs)
# iLOCi genes # Analyzed genes
(# SNPs)
# iLOCi genes
BD 654 42 (1757) 8 665 (16598) 52
CAD 710 29 (2097) 3 735 (11564) 37
CD 279 54 (1651) 4 531 (7181) 10
HT 595 32 (3164) 19 1240 (22004) 64
RA 677 34 (822) 4 503 (5902) 19
T1D 687 39 (1153) 5 512 (6924) 29
T2D 486 29 (1289) 5 2456 (41244) 110
  1. The table displays the number of previously reported disease-associated genes which were found in all analyzed genes and in the set of genes involved in top 1000 interaction pairs. The reported disease genes are shown for both the genes associated with disease SNPs from WTCCC paper [3] and the ones reported in HuGE Navigator database [33].