From: An approach to identifying drug resistance associated mutations in bacterial strains
Gene identifier | desc. | NS | NWS | OR | p-value | Gene functional annotation |
---|---|---|---|---|---|---|
Penicillin (NWS-threshold: 0.4) | ||||||
SAR0023(sasH) | G723D | 0.55 | 0.63 | 8.51 | 1.87e-05 | virulence-associated cell-wall-anchored protein; 5'-nucleotidase |
SAR0023(sasH) | T725A | 0.54 | 0.62 | 8.11 | 2.23e-05 | virulence-associated cell-wall-anchored protein; 5'-nucleotidase |
SAR0304 | V295I | 0.39 | 0.49 | 4.48 | 3.25e-04 | acid phosphatase |
SAR2791 | V182M | 0.46 | 0.46 | 6.05 | 5.41e-04 | transcriptional regulator, Xre family |
SAR2700 | N493KD | 0.52 | 0.45 | 7.72 | 6.16e-04 | ABC transporter permease protein |
SAR0233(hmp) | Q333K | 0.44 | 0.44 | 5.48 | 7.21e-04 | avohemoprotein (nitric oxide dioxygenase) |
SAR0318(sbnA) | N25HK | 0.44 | 0.43 | 5.48 | 8.36e-04 | alpha/beta family hydrolase |
SAR2664 | V282AT | 0.44 | 0.43 | 5.48 | 8.36e-04 | probable monooxygenase |
SAR2779 | S48G | 0.44 | 0.43 | 5.48 | 8.36e-04 | n-hydroxyarylamine o-acetyltransferase |
SAR0318(sbnA) | T138IM | 0.43 | 0.43 | 5.21 | 8.36e-04 | alpha/beta family hydrolase |
SAR0318(sbnA) | T139AQ | 0.43 | 0.43 | 5.21 | 8.36e-04 | alpha/beta family hydrolase |
SAR0023(sasH) | A749TG | 0.41 | 0.43 | 4.96 | 8.44e-04 | virulence-associated cell-wall-anchored protein; 5'-nucleotidase |
SAR0318(sbnA) | R130CG | 0.41 | 0.43 | 4.96 | 8.72e-04 | alpha/beta family hydrolase |
SAR0322(folC) | H201YQE | 0.41 | 0.43 | 4.96 | 8.72e-04 | macro domain, possibly adp-ribose binding module |
SAR0233(hmp) | K323ET | 0.40 | 0.42 | 4.71 | 9.08e-04 | avohemoprotein (hemoglobin-like protein) |
SAR2750(icaC) | I21V | 0.40 | 0.42 | 4.71 | 9.46e-04 | polysaccharide intercellular adhesin (PIA) biosynthesis protein |
SAR0233(hmp) | S309RN | 0.39 | 0.42 | 4.48 | 9.46e-04 | avohemoprotein (hemoglobin-like protein) |
Methicillin (NWS-threshold: 0.25) | ||||||
SAR0198(oppF) | T287IK | 0.10 | 0.29 | 2.11 | 1.41e-04 | putative glutathione transporter, ATP-binding component |
SAR0420 | I72F | 0.10 | 0.29 | 2.11 | 1.41e-04 | membrane protein |
SAR2508(sbi) | S219AT | 0.10 | 0.29 | 2.11 | 1.41e-04 | IgG-binding protein Sbi |
SAR2508(sbi) | N222QK | 0.10 | 0.29 | 2.11 | 1.41e-04 | IgG-binding protein Sbi |
SAR2508(sbi) | K224SDN | 0.10 | 0.29 | 2.11 | 1.41e-04 | IgG-binding protein Sbi |
Tetracycline (NWS-threshold: 0.2) | ||||||
SAR1840 | D291YS | 0.18 | 0.23 | 5.22 | 7.09e-04 | NAD(FAD)-utilizing dehydrogenases |
SAR2336(rpsJ) | K57M | 0.29 | 0.23 | 9.60 | 7.32e-04 | SSU ribosomal protein S10P (S20E) |
SAR0550(rpsL) | K113R | 0.36 | 0.20 | 13.33 | 1.14e-03 | SSU ribosomal protein S12P (S23E) |
Erythromycin (NWS-threshold: 0.2) | ||||||
SAR0576 | A68EV | 0.07 | 0.21 | 1.54 | 8.89e-04 | phosphoglycolate phosphatase |
Gentamicin (NWS-threshold: 0.21) | ||||||
SAR1840 | L289IW | 0.33 | 0.29 | 15.00 | 1.43e-03 | NAD(FAD)-utilizing dehydrogenases |
SAR1840 | D291YS | 0.33 | 0.29 | 15.00 | 1.43e-03 | NAD(FAD)-utilizing dehydrogenases |
SAR1840 | H327RF | 0.33 | 0.29 | 15.00 | 1.43e-03 | NAD(FAD)-utilizing dehydrogenases |
SAR1167(ylmH) | K215N | 0.25 | 0.29 | 10.00 | 1.43e-03 | RNA-binding S4 domain-containing protein |
SAR1167(ylmH) | R216V | 0.25 | 0.29 | 10.00 | 1.43e-03 | RNA-binding S4 domain-containing protein |
SAR1167(ylmH) | V217L | 0.25 | 0.29 | 10.00 | 1.43e-03 | RNA-binding S4 domain-containing protein |
SAR0547(rpoB) | D471YG | 0.17 | 0.21 | 6.00 | 4.61e-03 | DNA-directed RNA polymerase beta subunit |
SAR1833(trmB) | T54IK | 0.17 | 0.21 | 6.00 | 4.61e-03 | tRNA (guanine46-n7-)-methyltransferase |
Ciprooxacin (NWS-threshold: 0.12) | ||||||
SAR1367(grlA) | S80YF | 1.00 | 1.00 | 2244.00 | 6.03e-30 | topoisomerase IV subunit a |
SAR0006(gyrA) | S90AL | 0.94 | 0.88 | 1056.00 | 1.92e-18 | DNA gyrase subunit a |
SAR2449(lytT) | V45I | 0.21 | 0.20 | 17.11 | 2.06e-04 | transcriptional regulator |
SAR1840 | L289IW | 0.12 | 0.20 | 8.80 | 4.56e-04 | NAD(FAD)-utilizing dehydrogenases |
SAR1793(thiI) | A92ET | 0.09 | 0.20 | 6.39 | 2.06e-04 | thiamine biosynthesis protein thiI |
SAR2212(murA2) | A102T | 0.06 | 0.20 | 4.12 | 2.06e-04 | UDP-n-acetylglucosamine 1-carboxyvinyltransferase |
SAR1367(grlA) | E84KG | 0.26 | 0.15 | 23.76 | 9.40e-04 | topoisomerase IV subunit a |
SAR0235(pstG 1) | F401LV | 0.09 | 0.13 | 6.39 | 2.21e-03 | PTS system, maltose and glucose-specific IIC component |
SAR0400(nfrA) | R194H | 0.09 | 0.13 | 6.39 | 2.21e-03 | nitroreductase family protein |