Reproducibility analysis of function-based approach. The left figure (A) is the results of using pathway pairs from the same database, and the right figure (B) is the results of using pathway pairs cross databases. Each data point represents funSim score of a pathway pair. The dash lines represent the cut-off value (funSim = 0.5). If the points are located in the left-bottom and right-top corners, the prediction results of these pathway pairs are consistent. In contrast, the points located in the left-top and right-bottom corners indicate the inconsistent results.