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Table 3 KEGG pathways inferred from predicted ES proteins

From: Helminth secretome database (HSD): a collection of helminth excretory/secretory proteins predicted from expressed sequence tags (ESTs)

Parent KEGG pathway No. of ESPs Top KEGG pathway in the category
Carbohydrate metabolism 296 Citrate cycle (TCA cycle)
Lipid metabolism 221 Fatty acid metabolism
Amino acid metabolism 217 Valine, leucine and isoleucine degradation
Energy metabolism 188 Oxidative phosphorylation
Glycan biosynthesis and metabolism 167 N-Glycan biosynthesis
Nucleotide metabolism 137 Purine metabolism
Xenobiotics Biodegradation and Metabolism 104 Metabolism of xenobiotics by cytochrome P450, Drug metabolism - other enzymes
Metabolism of Cofactors and Vitamins 95 Riboflavin metabolism
Metabolism of other amino acids 70 Glutathione metabolism
Biosynthesis of other Secondary Metabolites 38 Isoquinoline alkaloid biosynthesis
Metabolism of Terpenoids and Polyketides 29 Terpenoid backbone biosynthesis, Limonene and pinene degradation
Genetic Information processing:
Folding, sorting and degradation 446 Protein processing in endoplasmic reticulum
Translation 334 RNA transport
Transcription 176 Spliceosome
Replication and repair 72 Nucleotide excision repair
Environmental information processing:
Signal transduction 243 MAPK signaling pathway
Signalling, molecules and interaction 23 Cell adhesion molecules (CAMs)
Membrane transport 6 ABC transporters
Cellular processes:
Transport and catabolism: 436 Lysosome
Cell Growth and Death 208 Cell cycle
Cell communication 130 Tight junction
Cell Motility 35 Regulation of actin cytoskeleton
Organismal systems:
Immune system 291 Antigen processing and presentation
Nervous System 186 Glutamatergic synapse
Endocrine system 172 Insulin signaling pathway
Digestive System 80 Pancreatic secretion
Circulatory System 52 Cardiac muscle contraction
Excretory System 51 Proximal tubule bicarbonate reclamation
Development 47 Axon guidance
Environmental Adaptation 30 Circadian rhythm - mammal
Sensory System 15 Phototransduction
Human Diseases:
Infectious Diseases 522 HTLV-I infection
Neurodegenerative Diseases 417 Alzheimer's disease
Cancers 241 Pathways in cancer (overview)
Cardiovascular Diseases 55 Hypertrophic cardiomyopathy (HCM), Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Immune Diseases 44 Rheumatoid arthritis
Endocrine and Metabolic Diseases 19 Type II diabetes mellitus