Table 3 KEGG pathways inferred from predicted ES proteins
Parent KEGG pathway | No. of ESPs | Top KEGG pathway in the category |
|---|---|---|
Metabolism: | ||
Carbohydrate metabolism | 296 | Citrate cycle (TCA cycle) |
Lipid metabolism | 221 | Fatty acid metabolism |
Amino acid metabolism | 217 | Valine, leucine and isoleucine degradation |
Energy metabolism | 188 | Oxidative phosphorylation |
Glycan biosynthesis and metabolism | 167 | N-Glycan biosynthesis |
Nucleotide metabolism | 137 | Purine metabolism |
Xenobiotics Biodegradation and Metabolism | 104 | Metabolism of xenobiotics by cytochrome P450, Drug metabolism - other enzymes |
Metabolism of Cofactors and Vitamins | 95 | Riboflavin metabolism |
Metabolism of other amino acids | 70 | Glutathione metabolism |
Biosynthesis of other Secondary Metabolites | 38 | Isoquinoline alkaloid biosynthesis |
Metabolism of Terpenoids and Polyketides | 29 | Terpenoid backbone biosynthesis, Limonene and pinene degradation |
Genetic Information processing: | ||
Folding, sorting and degradation | 446 | Protein processing in endoplasmic reticulum |
Translation | 334 | RNA transport |
Transcription | 176 | Spliceosome |
Replication and repair | 72 | Nucleotide excision repair |
Environmental information processing: | ||
Signal transduction | 243 | MAPK signaling pathway |
Signalling, molecules and interaction | 23 | Cell adhesion molecules (CAMs) |
Membrane transport | 6 | ABC transporters |
Cellular processes: | ||
Transport and catabolism: | 436 | Lysosome |
Cell Growth and Death | 208 | Cell cycle |
Cell communication | 130 | Tight junction |
Cell Motility | 35 | Regulation of actin cytoskeleton |
Organismal systems: | ||
Immune system | 291 | Antigen processing and presentation |
Nervous System | 186 | Glutamatergic synapse |
Endocrine system | 172 | Insulin signaling pathway |
Digestive System | 80 | Pancreatic secretion |
Circulatory System | 52 | Cardiac muscle contraction |
Excretory System | 51 | Proximal tubule bicarbonate reclamation |
Development | 47 | Axon guidance |
Environmental Adaptation | 30 | Circadian rhythm - mammal |
Sensory System | 15 | Phototransduction |
Human Diseases: | ||
Infectious Diseases | 522 | HTLV-I infection |
Neurodegenerative Diseases | 417 | Alzheimer's disease |
Cancers | 241 | Pathways in cancer (overview) |
Cardiovascular Diseases | 55 | Hypertrophic cardiomyopathy (HCM), Arrhythmogenic right ventricular cardiomyopathy (ARVC) |
Immune Diseases | 44 | Rheumatoid arthritis |
Endocrine and Metabolic Diseases | 19 | Type II diabetes mellitus |