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Table 2 Full list of 17 regulatory modules predictive of HCC metastasis.

From: Differential combinatorial regulatory network analysis related to venous metastasis of hepatocellular carcinoma

Module name Regulator Targets
hsa_miR_326_M hsa-miR-326 ARHGDIA, CEP250, MYO6, TYR, PWP2, RCBTB2, POLR3F
hsa_miR_323_3p_M hsa-miR-323-3p BCLAF1, SUMO1, TMBIM6, FAM168B
hsa_miR_16_M hsa-miR-16 NFATC3, ETNK1, BMX, NCOR2, POLR3F
hsa_let_7e_M hsa-let-7e CLP1, NGF
FOXO3_M FOXO3 MICAL1, SAMD8, FUBP3, ATXN10, ADAM11, RAB5C, MRPS24, DPAGT1, GPS1, SNRPC, SUMO1, TWF1, SAR1A, PICALM, TXNDC5, HEXIM2, TRIP12, ZDHHC15, SEMA4G, EFHD2
hsa_miR_22_M hsa-miR-22 SLC6A1, SLC35A4
hsa_miR_326_NM hsa-miR-326 MTERFD2, ARHGDIA, PCSK4, CEP250, PTRF, MYO6, ST6GALNAC6
hsa_miR_204_M hsa-miR-204 CHD5, ATF2, POU2F2, TOMM70A, WDR26, SPOP, FAM168B, PLAA, WASF2, SRXN1
POU2F2_M POU2F2 SPIB, C20ORF43, SUCNR1, PTRF
NFYB_M NFYB NTN4, CACNG5, C12ORF10, TUBA1B, CALB2, RGMA, APOC3, PGD, NDUFV1, CHDH, FBXO24, TCTN2
hsa_miR_30a_M hsa-miR-30a CREB1, PAWR, NEDD4, RRAS2, VPS26B, TBC1D2B, HTR4, ACAP2, ZFAND5, SPAG9, MICAL1, ATG5
hsa_miR_7_M hsa-miR-7 PDCD2, POLR2E, NF2, FAM168B, MEGF9
CUX1_NM CUX1 RUNX1, IFITM2, MARCH5, GPR21, RPL35, TNFRSF10B, CFP, SDHAF2, NUP62CL, YARS, NAGK, GRAMD1A, PLXNB2, BCL2L13, METTL11A, MARK3, ITM2A, HIP1R, BSG
FOXO3_NM FOXO3 MAFF, LEPROT, MICAL1, PSME1, SAMD8, FUBP3, ATXN10
STAT1_NM STAT1 MYBL1, MAFF, POLA1, EXOG, PGM1, ZDHHC4, WDR24, AMFR, RAD52, TMEM208, MRPL34, GCHFR, ANKRD30A, TRO, LDHAL6A, SERPING1, RNASE4, ARPC5L, SRSF3, CD248
TP53_NM TP53 ANKRD52, SLC25A20, PGM1, C1QTNF4, PKDCC
STAT1_M STAT1 WDR24, RAD52, GCHFR
  1. NM indicates the existence of the module in non-metastatic HCC gene regulatory network, M indicates the existence of the module in metastatic HCC gene regulatory network.