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Table 1 Ten weighting score matrices used in cross-species data integration and gene ranking.

From: Multi-species data integration and gene ranking enrich significant results in an alcoholism genome-wide association study

Weighting score matrix (WSM) Description
WSM1: (0.5,0.5,1,1,0.5,0.5,0.5,1) * HuAlc, HuAddChip, and Cross ** given 1, all others 0.5
WSM2: (0.5,0.5,1,1,0.5,0.5,0.5,0.5) HuAlc and HuAddChip given 1, all others 0.5
WSM3: (0.5,0.5,0.5,1,0.5,0.5,0.5,0.5) HuAddChip given 1, all others 0.5
WSM4: (0.5,0.5,1,1,1,0.5,0.5,0.5) All human data given 1, all others 0.5
WSM5: (1,1,1,1,0.5,0.5,0.5,0.5) All mouse data, human HuAlc and HuAddChip given 1, all others 0.5
WSM6: (1,1,0.5,0.5,0.5,0.5,0.5,0.5) All mouse data given 1, all others 0.5
WSM7: (1,1,1,1,1,0.5,0.5,0.5) All mouse and human data given 1, all others 0.5
WSM8: (0.5,0.5,0.5,1,0.5,0.5,0.5,1) HuAddChip and Cross given 1, all others 0.5
WSM9: (1,1,1,1,1,1,1,1) All given 1
WSM10: (1,1,1,1,1,1,1,0.5) All but Cross given 1
  1. * The weights in the parentheses are in the order for the datasets: MuAc, MuPref, HuAlc, HuAddChip, HuLink, Ce, Dr, Cross, respective. The description of these datasets is provided in Figure 1.
  2. ** Cross denotes the bonus score for genes who had cross-species hits except for genes from human linkage regions (see section Materials and methods).