Multi-species data integration and gene ranking enrich significant results in an alcoholism genome-wide association study

Table 1 Ten weighting score matrices used in cross-species data integration and gene ranking.

Weighting score matrix (WSM)	Description
WSM1: (0.5,0.5,1,1,0.5,0.5,0.5,1) *	HuAlc, HuAddChip, and Cross ** given 1, all others 0.5
WSM2: (0.5,0.5,1,1,0.5,0.5,0.5,0.5)	HuAlc and HuAddChip given 1, all others 0.5
WSM3: (0.5,0.5,0.5,1,0.5,0.5,0.5,0.5)	HuAddChip given 1, all others 0.5
WSM4: (0.5,0.5,1,1,1,0.5,0.5,0.5)	All human data given 1, all others 0.5
WSM5: (1,1,1,1,0.5,0.5,0.5,0.5)	All mouse data, human HuAlc and HuAddChip given 1, all others 0.5
WSM6: (1,1,0.5,0.5,0.5,0.5,0.5,0.5)	All mouse data given 1, all others 0.5
WSM7: (1,1,1,1,1,0.5,0.5,0.5)	All mouse and human data given 1, all others 0.5
WSM8: (0.5,0.5,0.5,1,0.5,0.5,0.5,1)	HuAddChip and Cross given 1, all others 0.5
WSM9: (1,1,1,1,1,1,1,1)	All given 1
WSM10: (1,1,1,1,1,1,1,0.5)	All but Cross given 1

* The weights in the parentheses are in the order for the datasets: MuAc, MuPref, HuAlc, HuAddChip, HuLink, Ce, Dr, Cross, respective. The description of these datasets is provided in Figure 1.
** Cross denotes the bonus score for genes who had cross-species hits except for genes from human linkage regions (see section Materials and methods).

ISSN: 1471-2164