Skip to main content

Table 1 Ten weighting score matrices used in cross-species data integration and gene ranking.

From: Multi-species data integration and gene ranking enrich significant results in an alcoholism genome-wide association study

Weighting score matrix (WSM)

Description

WSM1: (0.5,0.5,1,1,0.5,0.5,0.5,1) *

HuAlc, HuAddChip, and Cross ** given 1, all others 0.5

WSM2: (0.5,0.5,1,1,0.5,0.5,0.5,0.5)

HuAlc and HuAddChip given 1, all others 0.5

WSM3: (0.5,0.5,0.5,1,0.5,0.5,0.5,0.5)

HuAddChip given 1, all others 0.5

WSM4: (0.5,0.5,1,1,1,0.5,0.5,0.5)

All human data given 1, all others 0.5

WSM5: (1,1,1,1,0.5,0.5,0.5,0.5)

All mouse data, human HuAlc and HuAddChip given 1, all others 0.5

WSM6: (1,1,0.5,0.5,0.5,0.5,0.5,0.5)

All mouse data given 1, all others 0.5

WSM7: (1,1,1,1,1,0.5,0.5,0.5)

All mouse and human data given 1, all others 0.5

WSM8: (0.5,0.5,0.5,1,0.5,0.5,0.5,1)

HuAddChip and Cross given 1, all others 0.5

WSM9: (1,1,1,1,1,1,1,1)

All given 1

WSM10: (1,1,1,1,1,1,1,0.5)

All but Cross given 1

  1. * The weights in the parentheses are in the order for the datasets: MuAc, MuPref, HuAlc, HuAddChip, HuLink, Ce, Dr, Cross, respective. The description of these datasets is provided in Figure 1.
  2. ** Cross denotes the bonus score for genes who had cross-species hits except for genes from human linkage regions (see section Materials and methods).
Back to article page

BMC Genomics

ISSN: 1471-2164

Contact us