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Table 6 Functional enrichment test for the 47 top ranked genes using WebGestalt.

From: Multi-species data integration and gene ranking enrich significant results in an alcoholism genome-wide association study

GO ID* Term # genes p-value pBH**
GO:0007610 (BP) Behavior 11 1.17 × 10-7 5.08 × 10-5
GO:0007214 (BP) Gamma-aminobutyric acid signaling pathway 4 3.92 × 10-7 8.51 × 10-5
GO:0007154 (BP) Cell communication 29 7.66 × 10-7 0.0001
GO:0007631 (BP) Feeding behavior 5 2.16 × 10-6 0.0002
GO:0050794 (BP) Regulation of cellular process 37 3.00 × 10-6 0.0002
GO:0050789 (BP) Regulation of biological process 38 1.73 × 10-6 0.0002
GO:0033555 (BP) Multicellular organismal response to stress 4 3.21 × 10-6 0.0002
GO:0007186 (BP) G-protein coupled receptor protein signaling pathway 14 4.88 × 10-6 0.0002
GO:0007166 (BP) Cell surface receptor linked signal transduction 19 2.53 × 10-6 0.0002
GO:0065007 (BP) Biological regulation 38 8.70 × 10-6 0.0003
GO:0016917 (MF) GABA receptor activity 6 3.22 × 10-11 3.35 × 10-9
GO:0004890 (MF) GABA-A receptor activity 5 1.93 × 10-9 7.38 × 10-8
GO:0042165 (MF) Neurotransmitter binding 7 2.13 × 10-9 7.38 × 10-8
GO:0030594 (MF) Neurotransmitter receptor activity 6 3.56 × 10-8 9.26 × 10-7
GO:0005254 (MF) Chloride channel activity 6 6.04 × 10-8 1.26 × 10-6
GO:0005253 (MF) Anion channel activity 6 9.06 × 10-8 1.35 × 10-6
GO:0031404 (MF) Chloride ion binding 6 9.06 × 10-8 1.35 × 10-6
GO:0043168 (MF) Anion binding 6 2.64 × 10-7 3.43 × 10-6
GO:0005230 (MF) Extracellular ligand-gated ion channel activity 5 2.22 × 10-6 2.57 × 10-5
GO:0008509 (MF) Anion transmembrane transporter activity 6 3.99 × 10-6 4.15 × 10-5
GO:0045211 (CC) Postsynaptic membrane 8 2.22 × 10-9 1.86 × 10-7
GO:0034707 (CC) Chloride channel complex 6 6.57 × 10-9 2.76 × 10-7
GO:0044456 (CC) Synapse part 9 1.20 × 10-8 3.36 × 10-7
GO:0045202 (CC) Synapse 9 2.51 × 10-7 5.27 × 10-6
GO:0030054 (CC) Cell junction 9 5.88 × 10-6 9.88 × 10-5
GO:0034702 (CC) Ion channel complex 6 1.53 × 10-5 0.0002
GO:0044459 (CC) Plasma membrane part 16 1.70 × 10-5 0.0002
GO:0031226 (CC) Intrinsic to plasma membrane 11 0.0002 0.0019
GO:0005887 (CC) Integral to plasma membrane 11 0.0002 0.0019
GO:0033267 (CC) Axon part 3 0.0003 0.0025
  1. * BP: biological process; MF: molecular function; and CC: cellular component.
  2. ** BH: p-value corrected by the Benjamini-Hochberg method (1995) [50].