Table 3 KEGG pathways significantly enriched in the 218 differentially expressed genes
From: RNA-Seq analysis implicates dysregulation of the immune system in schizophrenia
KEGG pathway | Number of genes (%) | Nominal P-valuea | Adjusted P-valueb |
|---|---|---|---|
Antigen processing and presentation | 14 (6.42) | 9.27 × 10-18 | 1.58 × 10-16 |
Lysosome | 11 (5.05) | 1.07 × 10-11 | 9.09 × 10-11 |
Cell adhesion molecules (CAMs) | 10 (4.59) | 9.31 × 10-10 | 5.28 × 10-9 |
Hematopoietic cell lineage | 8 (3.67) | 9.68 × 10-9 | 4.11 × 10-8 |
MAPK signaling pathway | 11 (5.05) | 7.17 × 10-8 | 2.44 × 10-7 |
Chemokine signaling pathway | 9 (4.13) | 3.31 × 10-7 | 8.86 × 10-7 |
Systemic lupus erythematosus | 8 (3.67) | 3.65 × 10-7 | 8.86 × 10-7 |
Intestinal immune network for IgA production | 5 (2.29) | 3.89 × 10-6 | 8.27 × 10-6 |
Toll-like receptor signaling pathway | 6 (2.75) | 8.76 × 10-6 | 1.65 × 10-5 |
T cell receptor signaling pathway | 6 (2.75) | 1.29 × 10-5 | 2.19 × 10-5 |
Epithelial cell signaling in Helicobacter pylori infection | 5 (2.29) | 1.79 × 10-5 | 2.77 × 10-5 |
Leukocyte transendothelial migration | 6 (2.75) | 2.13 × 10-5 | 3.02 × 10-5 |
B cell receptor signaling pathway | 5 (2.29) | 2.88 × 10-5 | 3.77 × 10-5 |
Ribosome | 5 (2.29) | 6.23 × 10-5 | 7.56 × 10-5 |
Cytokine-cytokine receptor interaction | 6 (2.75) | 0.0017 | 0.0019 |
Metabolic pathways | 13 (5.96) | 0.0023 | 0.0024 |
Pathways in cancer | 6 (2.75) | 0.0049 | 0.0049 |