Skip to main content

Table 3 KEGG pathways significantly enriched in the 218 differentially expressed genes

From: RNA-Seq analysis implicates dysregulation of the immune system in schizophrenia

KEGG pathway Number of genes (%) Nominal P-valuea Adjusted P-valueb
Antigen processing and presentation 14 (6.42) 9.27 × 10-18 1.58 × 10-16
Lysosome 11 (5.05) 1.07 × 10-11 9.09 × 10-11
Cell adhesion molecules (CAMs) 10 (4.59) 9.31 × 10-10 5.28 × 10-9
Hematopoietic cell lineage 8 (3.67) 9.68 × 10-9 4.11 × 10-8
MAPK signaling pathway 11 (5.05) 7.17 × 10-8 2.44 × 10-7
Chemokine signaling pathway 9 (4.13) 3.31 × 10-7 8.86 × 10-7
Systemic lupus erythematosus 8 (3.67) 3.65 × 10-7 8.86 × 10-7
Intestinal immune network for IgA production 5 (2.29) 3.89 × 10-6 8.27 × 10-6
Toll-like receptor signaling pathway 6 (2.75) 8.76 × 10-6 1.65 × 10-5
T cell receptor signaling pathway 6 (2.75) 1.29 × 10-5 2.19 × 10-5
Epithelial cell signaling in Helicobacter pylori infection 5 (2.29) 1.79 × 10-5 2.77 × 10-5
Leukocyte transendothelial migration 6 (2.75) 2.13 × 10-5 3.02 × 10-5
B cell receptor signaling pathway 5 (2.29) 2.88 × 10-5 3.77 × 10-5
Ribosome 5 (2.29) 6.23 × 10-5 7.56 × 10-5
Cytokine-cytokine receptor interaction 6 (2.75) 0.0017 0.0019
Metabolic pathways 13 (5.96) 0.0023 0.0024
Pathways in cancer 6 (2.75) 0.0049 0.0049
  1. aNominal P-value was calculated by hypergeometric test.
  2. bAdjusted P-values was corrected of nominal P-values by Benjamini-Hochberg multiple testing correction.
\