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Table 2 Significantly associated GO terms to only cancer-generic or tissue-centric contextual gene sets

From: Learning contextual gene set interaction networks of cancer with condition specificity

GO terms relevant only to cancer-generic

GO terms relevant only to tissue-centric

contextual gene sets

contextual gene sets

GO term

Frequency

GO term

Frequency

GO:0007166: cell surface receptor signal transduction

11

GO:0006163: purine nucleotide metabolism

2

GO:0007049: cell cycle

9

GO:0006164: purine nucleotide biosynthesis

2

GO:0006396: RNA processing

7

GO:0006629: lipid metabolism

2

GO:0008283: cell proliferation

7

GO:0009150: purine ribonucleotide metabolism

2

GO:0016070: RNA metabolism

7

GO:0009152: purine ribonucleotide biosynthesis

2

GO:0043207: response to external biotic stimulus

7

GO:0009259: ribonucleotide metabolism

2

GO:0000375: RNA splicing, via transesterification reactions

6

GO:0009260: ribonucleotide biosynthesis

2

GO:0000377: RNA splicing, via transesterification reactions

6

GO:0044255: cellular lipid metabolism

2

GO:0000398: nuclear mRNA splicing, via spliceosome

6

GO:0046148: pigment biosynthesis

2

GO:0006397: mRNA processing

6

GO:0000904: cellular morphogenesis

1

GO:0006959: humoral immune response

6

GO:0006099: tricarboxylic acid cycle

1

GO:0008380: RNA splicing

6

GO:0006119: oxidative phosphorylation

1

GO:0009613: response to pest, pathogen or parasite

6

GO:0006144: purine base metabolism

1

GO:0016071: mRNA metabolism

6

GO:0006188 : IMP biosynthesis

1

GO:0030333: antigen processing

6

GO:0006189: ’de novo’ IMP biosynthesis

1

GO:0000067: DNA replication and chromosome cycle

5

GO:0006510: ATP-dependent proteolysis

1

GO:0000075: cell cycle checkpoint

5

GO:0006554: lysine catabolism

1

GO:0006950: response to stress

5

GO:0006570: tyrosine metabolism

1

GO:0016064: humoral defense mechanism

5

GO:0006582: melanin metabolism

1

GO:0000279: M phase

4

GO:0006583: melanin biosynthesis from tyrosine

1

  1. The frequency indicates the number of contextual gene sets associated with the corresponding GO term. Only 20 most frequent terms are shown for each case.