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Table 2 Significantly associated GO terms to only cancer-generic or tissue-centric contextual gene sets

From: Learning contextual gene set interaction networks of cancer with condition specificity

GO terms relevant only to cancer-generic GO terms relevant only to tissue-centric
contextual gene sets contextual gene sets
GO term Frequency GO term Frequency
GO:0007166: cell surface receptor signal transduction 11 GO:0006163: purine nucleotide metabolism 2
GO:0007049: cell cycle 9 GO:0006164: purine nucleotide biosynthesis 2
GO:0006396: RNA processing 7 GO:0006629: lipid metabolism 2
GO:0008283: cell proliferation 7 GO:0009150: purine ribonucleotide metabolism 2
GO:0016070: RNA metabolism 7 GO:0009152: purine ribonucleotide biosynthesis 2
GO:0043207: response to external biotic stimulus 7 GO:0009259: ribonucleotide metabolism 2
GO:0000375: RNA splicing, via transesterification reactions 6 GO:0009260: ribonucleotide biosynthesis 2
GO:0000377: RNA splicing, via transesterification reactions 6 GO:0044255: cellular lipid metabolism 2
GO:0000398: nuclear mRNA splicing, via spliceosome 6 GO:0046148: pigment biosynthesis 2
GO:0006397: mRNA processing 6 GO:0000904: cellular morphogenesis 1
GO:0006959: humoral immune response 6 GO:0006099: tricarboxylic acid cycle 1
GO:0008380: RNA splicing 6 GO:0006119: oxidative phosphorylation 1
GO:0009613: response to pest, pathogen or parasite 6 GO:0006144: purine base metabolism 1
GO:0016071: mRNA metabolism 6 GO:0006188 : IMP biosynthesis 1
GO:0030333: antigen processing 6 GO:0006189: ’de novo’ IMP biosynthesis 1
GO:0000067: DNA replication and chromosome cycle 5 GO:0006510: ATP-dependent proteolysis 1
GO:0000075: cell cycle checkpoint 5 GO:0006554: lysine catabolism 1
GO:0006950: response to stress 5 GO:0006570: tyrosine metabolism 1
GO:0016064: humoral defense mechanism 5 GO:0006582: melanin metabolism 1
GO:0000279: M phase 4 GO:0006583: melanin biosynthesis from tyrosine 1
  1. The frequency indicates the number of contextual gene sets associated with the corresponding GO term. Only 20 most frequent terms are shown for each case.