Table 1 Human G protein-coupled receptor signaling pathway profile in erythroid progenitor cells, of peripheral blood origin, after treatment with hydroxycarbamide

Beta 2 adrenergic receptor

0,04±0,04

0,15±0,1

D1 dopamine receptor

0,12±0,1

0,34±0,2

D2 dopamine receptor

0,13±0,02

0,28±0,1

D5 dopamine receptor

1,23±0,4

2,03±1,1

Sphingosine-1-phosphate receptor 2

1,92±0,4

2,6±1,1

Human DP prostanoid receptor

0,39±0,1

0,76±0,1

Prostaglandin E receptor 1, EP1 subtype

1,02±0,2

1,89±0,5

PI-3 kinase pathway:

v-akt murine thymoma viral oncogene homolog 1

0,04±0,01

0,07±0,06

cAMP/PKA pathway:

Adiponectin, C1Q and collagen domain containing

0,28±0,09

0,87±0,2

NO/cGMP pathway:

PRP18 pre-mRNA processing factor 18 homolog

0,36±0,28

0,93±0,6

PKC pathway (Ca ²⁺ ,MEK, etc.):

Luteinizing hormone beta polypeptide

0,8±0,1

1±0,4

Jun B proto-oncogene,

0,08±0,08

0,12±0,1

Interleukin 8

0,07±0,04

0,24±0,3

ETS-domain protein (SRF accessory protein 1)

0,69±0,12

0,56±0,2

JAK-STAT pathway:

Heat shock 70 kDa protein 4

0,34±0,1

0,35±0,14

Heat shock 90 kDa protein 1, alpha

1,84±0,5

2,21±1,2

Suppressor of cytokine signaling 1

0,84±0,4

2,25±0,96

Hydroxy-delta-5-steroid dehydrogenase

0,09±0,02

0,17±0,03

MAP kinase pathway (p42/p44MAP, p38MAP):

Plasminogen activator inhibitor, type I

0,11±0,1

0,13±0,06

v-jun avian sarcoma virus 17 oncogene homolog

0,13±0,04

0,21±0,01

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein

1,36±0,3

1,28±0,3

Human helix-loop-helix zipper protein

0,05±0,01

0,21±0,2