Figure 3From: Comparative genomics using teleost fish helps to systematically identify target gene bodies of functionally defined human enhancersPredicting the target genes of human enhancers by paralogy and orthology mapping of locus architecture. (A) CNE-enhancers when duplicated are retained with their target genes. Comparing the genic content of CNE-EBF containing paralogous loci in human genome and their orthologous loci in multiple fish lineages unmistakably suggests that duplicated copies of human CNE-EBF enhancer (hs230) are associated with the regulation of paralogous copies of EBF family members, i.e. EBF1, EBF3 and EBF4. (B) Unduplicated CNE-enhancer (hs529) is associated with its target gene SH3GL2 by tracing the differential loss of unrelated bystander genes among orthologous loci. Genes are color-coded. Direction of arrow depicts the direction of gene transcription. Light green vertical line depicts the position of CNE-enhancer. Horizontal black line depicts scale.Back to article page