Human enhancer regions can access their target promoters from a distance of ~2 MB. Evolutionary conserved syntenic association between a CNE-enhancer (hs191) and human NR2F1 and harmony in their expression pattern domains in mice infers the functional association among them. The distance between the transcription start site of human NR2F1 and concerned cis-acting site is ~2 MB. Genes are color-coded. Direction of arrow depicts the direction of gene transcription. Light green vertical line depicts the position of CNE-enhancer. Horizontal black line depicts scale.