Comparative genomics using teleost fish helps to systematically identify target gene bodies of functionally defined human enhancers

Table 1 The association of the human CNE-enhancers with their target gene bodies by comparative syntenic analyses and through comparison of the reporter expression induced by CNE-enhancers with the reported endogenous expression patterns of the neighboring genes

No. of enhancers	No. of target genes	Technique used		Minimal evidence for association
		Paralogy mapping (duplication)	Orthology mapping (synteny)	Only synteny	Synteny along with expression (MGI *in-situ*)
39	1	√	√	√	¯
2	2	√	√	¯	√
1	1	√	√	¯	√
1	1	√	√	√	*
41	2	¯	√	¯	√
7	3	¯	√	¯	√
44	1	¯	√	√	¯
56	1	¯	√	¯	√
1	1	¯	√	√	*

This table provides the following information about human CNE-enhancers.
(i) The number of target genes associated with each CNE-enhancer analyzed.
(ii) Whether they are duplicated or not.
(iii) Their association with target gene is supported by either syntenic analysis or by endogenous expression analysis or by both.
* Expression pattern is not known.
MGI: Mouse Genome Informatics.
CNE: Conserved non-coding element.

ISSN: 1471-2164