Validation steps and CNV profiles as a function of different Bayes factor thresholds. (a) Density plot of the number of redundant and non-redundant CNVs in samples bearing CNVs and (b) of the CNV regions for each CNV as a function of the indicated thresholds. Vertical lines indicate the adjusted R2 values with the different Bayes factor (BF) thresholds (BF/R2;10/0.86; 15:0.92; 20/0.93; 30/0.94). (c) Correlation between the number of CNVs and the results of qRT-PCR experiments (p0.0001; R2: 0.9234). (d) Log R ratio (LRR) and B allele frequency (BAF) plots of three copy-number variants (CN: 0, position: Chr6:48491442–48639804; CN: 1, position:Chr6:117809568–122543361; CN: 3, position: Chr11:107086182–110171704).