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Table 1 Possible role for uncharacterized TFs in S. aureus USA300

From: Global analysis of transcriptional regulators in Staphylococcus aureus

Protein ID TF Family Identities and comments References
SAUSA300_0063 Crp Present in the ACME element [9]
SAUSA300_0093 LysR YwqM (30.2%) and GltR (27.9%), in B. subtilis. The latter appears to be involved in glutamate synthase expression. [10]
SAUSA300_0095 LysR PtxR of Pseudomonas aeruginosa PAO1 (41.5%) and Yersinia pestis (38.7%). Activates the expression of exotoxins and represses the expression of quorum sensing related genes. [11, 12]
SAUSA300_0104 AraC Btr (24.5%) from B. subtilis. One-component regulator that controls siderophore transport [13]
SAUSA300_0137 GntR TreR (37%), involved in the regulation of trehalose related genes in B. subtilis. It is encoded divergent to purine synthesis genes. [14]
SAUSA300_0217 TCS-RR YesN (38.4%) and DegU (35.8%) from B. subtilis. The latter is involved in the expression of proteases and biofilm. [15]
SAUSA300_0238 BglG MnaR (25%) from B. subtilis  
SAUSA300_0258 GntR LutR (44.4%), involved in regulation of lactate and biofilm in B. subtilis. It has a UbiC transcription regulator-associated (UTRA) domain. [16]
SAUSA300_0333 BglG LicR (28.5%) from B. subtilis. Regulates the transport and degradation of oligomeric beta-glucosides [17]
SAUSA300_0350 Xre YgzD (46%) B. subtilis  
SAUSA300_0373 Xre No identity to characterized proteins  
SAUSA300_0503 GntR YdeL (36%) and GabR (32.3%) both from B. subtilis. GabR regulates the expression of GABA synthesis genes. It also has some identity to S. aureus NorG (23%). It has a pyridoxal phosphate (PLP)-dependent aspartate aminotransferase domain. [18]
SAUSA300_0577 GntR This is the first gene in a putative operon with a pyridine nucleotide-disulphide oxidoreductase.  
SAUSA300_0658 LysR E. coli OxyR (29.4%), positive regulator for a hydrogen peroxide-inducible regulon. Possible CcpC homolog, involved in regulation of TCA. [19]
SAUSA300_0683 GntR IolR (30.9%), repressor or the myo-inositol operon in B. subtilis. Its genomic context shows that it may regulate genes involved in fructose metabolism. [20]
SAUSA300_0803 Xre Toxin-antitoxin systems. These systems may contribute to the preservation of plasmids and genetic islands, however the role of many of them is still unknown [21]
SAUSA300_0804 Xre Toxin-antitoxin system [21]
SAUSA300_0878 LysR CytR (25%), regulator of the citrate synthase genes in B. subtilis. In S. aureus it is divergent to isopropylmalate synthase involved in Leu and pyruvate metabolism. [22]
SAUSA300_0858 Rps1 B. subtilis YabR (42%), putative polyribonucleotide nucleotidyl transferase  
SAUSA300_0928 ComK B. subtilis ComK (33.9%), required for genetic competence [23]
SAUSA300_0954 MarR YdgJ (35.4%), B. subtilis  
SAUSA300_0998 Xre Rpc (33.7%) from B. subtilis bacteriophage phi 105. Involved in the regulation of lysogeny.  
SAUSA300_1170 GntR YmfC (34.3%), B. subtilis. It has a UbiC transcription regulator-associated (UTRA) domain.  
SAUSA300_1174 GntR YmfK (65%), B. subtilis  
SAUSA300_1175 GntR YmfM (31.25%) B. subtilis  
SAUSA300_1204 Xre No identity to characterized proteins  
SAUSA300_1220 TCS-RR LuxR-like protein with identity to DesR (43.2%), responsible for thermosensing and signal transduction at low temperatures in B. subtilis. Also has identity to YvfU (45%) from B. subtilis [24]
SAUSA300_1424 Unknown No identity to characterized proteins  
SAUSA300_1433 Xre No identity to characterized proteins  
SAUSA300_1434 Xre Toxin-antitoxin system [21]
SAUSA300_1455 AraC AarP (30.8%), involved in regulation of 2'-N-acetyltransferase in Providencia stuartii. [25]
SAUSA300_1469 ArgR 28% identity with S.aureus ArgR. In operon with a DNA repair protein  
SAUSA300_1914 GltR B. subtilis YtrA (39.45%), possible repressor of an operon for a putative ATP-binding cassette transport system involved in acetoin utilization. YtrA is an additional regulator of cell envelope stress responses in B. subtilis. [26, 27]
SAUSA300_1946 RinB RinB (76%) from phage 11. Activates int gene expression [28]
SAUSA300_1968 Xre No identity to characterized proteins  
SAUSA300_1969 Xre LexA (28%), SOS regulator in E. coli  
SAUSA300_2077 HxlR B. subtilis YodB (38.46%), regulation of yocJ (azoR1) after exposure to thiol-reactive compounds. A similar gene in B. subtilis regulates formaldehyde detoxification via hxlAB. In S. aureus it is not close to these genes, even though they are present in the genome. [29]
SAUSA300_2106 BglG ManR_(23.6%), mannose utilization in B. subtilis [30]
SAUSA300_2160 MerR AdhR (38%) B. subtilis. Transcriptional regulator involved in the response to aldehyde stress. [31]
SAUSA300_2216 MarR YwoH (31.6%) from B. subtilis  
SAUSA300_2248 AraC E. coli YijO (28.6%), might be involved in the regulation of genes encoding enzymes related to PTS systems [32]
SAUSA300_2261 GntR No identity to characterized proteins  
SAUSA300_2300 TetR No identity to characterized proteins. Divergent to 2 multidrug transport proteins (emrAB homologs)  
SAUSA300_2310 LytTr Bears a LytTR domain, which is an only recently characterized family.  
SAUSA300_2322 TetR B. subtilis YxbF (42.4%). In S. aureus it is in an operon with a CorA Mg transporter  
SAUSA300_2336 MerR CueR (42.8%), involved in copper induction in B. subtilis. [33]
SAUSA300_2445 MerR 36% identical to BltR, B. subtilis, and MerR (31%), S. aureus. The former is involved in response to structurally dissimilar drugs, while the latter is on a plasmid specifying resistance for mercurial compounds. [34, 35]
SAUSA300_2547 Unknown B. subtilis YuaC (55.4%)  
SAUSA300_2452 MarR Similar to B. subtilis YvnA (35.8%), (29%) and AdcR from Streptococcus pneumoniae. AdcR is able to sense metals for the regulation of zinc uptake proteins related genes encoding cell-surface zinc-binding pneumococcal histidine triad proteins and AdcAII (laminin binding). Also has a 33% identity to SarZ [36]
SAUSA300_2459 MarR MhqR (41.5%) regulates multiple dioxygenases/glyoxalases and an azoreductase that confer resistance to 2-methylhydroquinone and catechol in B. subtilis [37]
SAUSA300_2490 LysR No identities to characterized proteins. Divergent to operon encoding mmpL (transporter) and Feo iron dependent transporters  
SAUSA300_2509 TetR B. subtilis YxbF (31.6%).  
SAUSA300_2515 TetR SlmA (26.2%) in Vibrio parahaemolyticus. SlmA proteins are involved in nucleoid occlusion systems in E. coli. In S. aureus it is in an operon with genes encoding an oxidoreductase, an amidohyrolase and a hydrolase. [38]
SAUSA300_2530 TetR No identity to characterized proteins.  
SAUSA300_2563 MarR PetP, (33.06%), necessary for photosynthetic and respiratory growth in Rhodobacter capsulatus [39]
SAUSA300_2575 BglG No identity to characterized proteins.  
SAUSA300_2640 Xre ImmR (46% identity), involved in mobilization of the genetic element ICEB1 in B. subtilis [40, 41]
SAUSA300_2625 PadR PadR (37.5%), repressor of phenolic acid response genes in B. subtilis [42]
  1. Amino acid sequences of uncharacterized TFs (Figure 2) were analyzed by using BLAST comparisons against the NR and SwissProt databases. In the third column is shown the closest identified protein (s), and their functional roles in corresponding organisms.