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Figure 4 | BMC Genomics

Figure 4

From: A Drosophila functional evaluation of candidates from human genome-wide association studies of type 2 diabetes and related metabolic traits identifies tissue-specific roles for dHHEX

Figure 4

Metabolic profiling of Cg>RNAidHHEX-V15721, Dcr-2. A. Wandering third-instar females of Cg>RNAidHHEX-V15721, Dcr-2 are hyperglycemic. Each measurement is made from a pooled sample of hemolymph from 5–8 animals; dark red line segments show mean values. p < 0.029. BC. Wandering third-instar and newly eclosed adult females of Cg>RNAidHHEX-V15721, Dcr-2 have reduced body size. Each measurement is the mean per-animal mass of a group of 6–10 animals; dark red line segments show mean values. p < 0.001 for both larvae and adults. DE. Wandering third-instar and newly eclosed adult females of Cg>RNAidHHEX-V15721, Dcr-2 have reduced triglyceride levels. Each measurement is made from a pooled sample of whole-animal homogenate from 6–10 animals; dark red line segments show mean values. p < 0.007 for both larvae and adults (p < 0.002 for adults when one extreme outlier is excluded). All p-values for metabolic data were calculated using a bidirectional t-test without assuming equal variances. More complete details are in Additional file 1: Tables S6–S8.

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