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Table 1 Human genes identified by GWAS

From: A Drosophila functional evaluation of candidates from human genome-wide association studies of type 2 diabetes and related metabolic traits identifies tissue-specific roles for dHHEX

Region Trait Genes
1p32.3 LDL TMEM61, BSND, PCSK9, USP24
1p31.3 TG ANGPTL3*, DOCK7, ATG4C**
1p13.3 LDL KIAA1324, SARS, CELSR2**, PSRC1, MYBPHL, SORT1
1p12 T2D ADAM30, NOTCH2
1q42.13 TG, HDL GALNT2
2p24.1 LDL APOB
2p23.3 T2D NRBP1**, KRTCAP3, IFT172, FNDC4, GCKR, C2orf16, ZNF512
2p21 T2D THADA**, PLEKHH2
2q24.3 FG NOSTRIN*, SPC25, G6PC2, ABCB11**
3p25.2 T2D PPARG**
3p14.1 T2D ADAMTS9*
3q27.3 T2D IGF2BP2*, C3orf65
5q13.3 LDL HMGCR, COL4A3BP
6p22.3 T2D CDKAL1
6p21.32 LDL HLA-DPA1, COL11A2, RXRB**, SLC39A7, HSD17B8, MIR219-1, RING1**, VPS52, RPS18
7p15.2 T2D JAZF1
7p13 FG AEBP1, MIR4649, POLD2, MYL7, GCK**, YKT6, CAMK2B
7q11.23 TG BAZ1B, BCL7B, TBL2, MLXIPL**, VPS37D, DNAJC30*, WBSCR22, STX1A
8p21.3 TG, HDL LPL**
8q24.11 T2D SLC30A8*
8q24.13 TG TRIB1*
9p21.3 T2D MTAP, CDKN2A, CDKN2B
9q31.1 HDL ABCA1
10p13 T2D NUDT5, CDC123, CAMK1D
10q23.33 T2D IDE*, KIF11*, HHEX**
10q25.2 T2D TCF7L2**
11p15.1 T2D NUCB2*, NCR3LG1, KCNJ11**, ABCC8*
11p11.2 T2D EXT2, ALX4
11q23.3 TG BUD13, ZNF259, APOA5, APOA4, APOC3, APOA1, SIK3
12q15 T2D TSPAN8, LGR5
12q23.3 HDL MYO1H, KCTD10*, UBE3B, MMAB, MVK**
15q21.3 HDL LIPC**
16q12.1 T2D RPGRIP1L, FTO
16q12.2 HDL CETP, NLRC5, SLC12A3**, HERPUD1, MIR138-2
18q21.1 HDL LIPG**, ACAA2
19p13.2 LDL SMARCA4, LDLR, SPC24, KANK2
19p13.11 TG, LDL GATAD2A, TSSK6, NDUFA13**, YJEFN3, CILP2, PBX4, LPAR2, GMIP, ATP13A1**
19q13.33 LDL BCL3, CBC, BCAM, PVRL2, TOMM40**, APOE, APOC1, APOC4, APOC2, CLPTM1, RELB**
  1. List of all human genes located near the SNPs considered in the study. Asterisks indicate genes with Drosophila orthologs that function in sucrose tolerance in Drosophila; doubled asterisks indicate strong hits. Italicized genes were not evaluated in the Drosophila sucrose-intolerance screen, mostly because they lack Drosophila orthologs. References and more detailed experimental results are in Additional file 1: Table S1.