Table 3 Top 10 IPA-derived upstream regulators, by absolute activation z-score
A | |||||
|---|---|---|---|---|---|
Upstream Regulator | Log Ratio | Molecule Type | Predicted Activation State | Activation z-score | p-value of overlap |
TP53 | transcription regulator | Inhibited | −4.88 | 1.05E-16 | |
CDKN1A | −0.469 | kinase | Inhibited | −3.274 | 4.20E-10 |
TRAF2 | enzyme | Activated | 2.804 | 3.06E-06 | |
CCNK | other | Activated | 2.905 | 3.83E-04 | |
TNF | cytokine | Activated | 2.935 | 7.69E-04 | |
IL1B | cytokine | Activated | 2.952 | 1.76E-01 | |
TP63 | transcription regulator | Activated | 3.181 | 8.37E-10 | |
TREM1 | other | Activated | 3.352 | 3.69E-05 | |
FOXM1 | 1.37 | transcription regulator | Activated | 4.28 | 3.71E-17 |
Mek | group | Activated | 4.336 | 2.38E-07 | |
B | |||||
Upstream Regulator | Log Ratio | Molecule Type | Predicted Activation State | Activation z-score | p-value of overlap |
TP53 | 0.622 | transcription regulator | Inhibited | −5.749 | 6.48E-12 |
TGM2 | enzyme | Inhibited | −4.243 | 3.64E-02 | |
CDKN1A | −0.485 | kinase | Inhibited | −3.548 | 1.85E-10 |
KDM5B | transcription regulator | Inhibited | −3.126 | 3.31E-08 | |
NFkB (complex) | complex | Activated | 3.034 | 3.59E-03 | |
TREM1 | other | Activated | 3.073 | 2.18E-05 | |
TP63 | transcription regulator | Activated | 3.63 | 6.25E-06 | |
IL1B | cytokine | Activated | 3.686 | 4.13E-01 | |
FOXM1 | 1.29 | transcription regulator | Activated | 3.925 | 5.82E-11 |
Mek | group | Activated | 4.771 | 7.08E-08 | |
C | |||||
Upstream Regulator | Log Ratio | Molecule Type | Predicted Activation State | Activation z-score | p-value of overlap |
TP53 | transcription regulator | Inhibited | −5.126 | 1.30E-13 | |
CDKN1A | −0.496 | kinase | Inhibited | −3.534 | 5.99E-10 |
TGM2 | enzyme | Inhibited | −3.402 | 4.25E-02 | |
miR-483-3p | mature microRNA | Inhibited | −3.153 | 6.49E-03 | |
EGFR | kinase | Activated | 3.104 | 4.43E-03 | |
IL1B | cytokine | Activated | 3.281 | 1.73E-01 | |
TP63 | transcription regulator | Activated | 3.524 | 1.48E-09 | |
TREM1 | other | Activated | 3.845 | 5.74E-06 | |
FOXM1 | 1.398 | transcription regulator | Activated | 4.386 | 4.18E-16 |
Mek | group | Activated | 4.654 | 9.72E-08 |