Skip to main content

Table 1 Putative function of genes with increased expression of 15-fold* or more in choroid plexus compared to striatum and parietal cortex under control conditions

From: Comparison of the global gene expression of choroid plexus and meninges and associated vasculature under control conditions and after pronounced hyperthermia or amphetamine toxicity

Choroid plexus expression relative to striatum and parietal cortex expression

NCBI gene symbols

Tissue specificity or reported function(s)

> 50-fold

Col8a1, Esm1, Glycam1, Lect1, Thbs2

Vasculature & Heart

> 50-fold

A2m, Pla2g5, Xcl1

Immune System

> 50-fold

Adipoq , Pon1, Pon3

Retinoic Acid & Lipid Processing

> 50-fold

Cldn1 , Crb3, Fmod, Kl a , Steap1, Tmem27

Extracellular Matrix & Cell-Cell Junctions

> 50-fold

Aqp1 , Atp4a, Clic6, Kcne2 , Kcnj13, Slc4a5, Slc5a5 , Slc16a8, Slco1a5, Ttr , Trpm3

Ion & Solute Transport & Homeostasis

> 50-fold

Cdkn1c, Folr1, Igfbp2, Mpzl2, Msx1,Otx2, Sostdc1

Development & Transcription Regulation

> 50-fold

Cox8h, Efhb, Epn3 , Fscn2, Klc3, Krt18, Scgb1c1

Unknown & Miscellaneous

30 to 50-fold

Lepr, Mdk, Ogn , Tnni2

Vasculature & Heart

30 to 50-fold

Cd74 a , Klra5 , Nphs1, RT1-Da, Serpinb1a

Immune System

30 to 50-fold

Cldn2 , Dcn, Lama2, Lgals3bp , Rsph4a

Extracellular Matrix & Cell-Cell Junctions

30 to 50-fold

Slc4a2, Slc26a7

Ion & Solute Transport & Homeostasis

30 to 50-fold

Apoa2, Lrat

Retinoic Acid & Lipid Processing

30 to 50-fold

Msx3, NTF4, Wfikkn2

Development & Transcription Regulation

30 to 50-fold

Atp11c, Copz2, Dhrs7c , Dmrt3, F5 , Klk4, Krt8, Nt5dc2 , Pdlim2 , Phactr2 , Sah, Scara5, Spag8,

Unknown & Miscellaneous

15 to 30-fold

Ace , Anxa2 a , Cox8h , Itgb6, Trim63

Vasculature & Heart

15 to 30-fold

Cmtm8, Ctsc , Igsf1, RT1-Db1

Immune System

15 to 30-fold

Adamtsl4 , Col9a3, Dsp, Loxl1, Mmp14 , Prelp , Sulf1

Extracellular Matrix & Cell-Cell Junctions

15 to 30-fold

Fxyd1, Slc12a4, Slc16a12 , Slc19a1 , Slc25a30, Sned1

Ion & Solute Transport & Homeostasis

15 to 30-fold

Agpat2, Enpp2, Gprc5c , Rbp2

Retinoic Acid & Lipid Processing

15 to 30-fold

Cdkn1a, Dab2, Igf2 , Nr1i2, Prrx2, Sfrp1, Zic4

Development & Transcription Regulation

15 to 30-fold

Akap14, Capn3, Capsl, Ccdc37, Dse , Elmo3, Hdc, Hspb1 , Iqcg, Kpl2, Lhb, Mesp1 , Nudt7, Otc, Paqr5, Ppp1r3b, Pqlc3 , Tsga2, Sod3, Spata6, Spint2 , Sult1c1

Unknown & Miscellaneous

  1. * Genes included in the table must have been more than 15-fold above expression in the choroid plexus compared to both the striatum and parietal cortex and at least 5-fold above the background level. Also, expression must have been relatively consistent across individual control animals so that the S.D. was less than the mean. The lower of the two ratios (choroid plexus/striatum or choroid plexus/parietal cortex) for each gene was used for grouping. Genes were categorized using NCBI Entrez Gene.
  2. aGenes found in endothelial cells that also likely play a major role in mediating immune responses.
  3. Bold font indicates gene expression was also at least 15-fold greater in MAV compared to both the striatum and parietal cortex.
  4. Underlined font indicates gene expression was also at least 10- to 15-fold greater in MAV compared to both the striatum and parietal cortex.