Table 6 Genes with significant differential expression between AMPH and EIH at 3 hr in MAV

A3galt2

2

T-cell function?

NCBI Entrez Gene

Abca1

2.18

ATP-binding cassette (ABC) transporters

Cholesterol transport

NCBI Entrez Gene

Actn3

2.47

Cross links actin containing filaments

NCBI Entrez Gene

Ada

0.41

Adenosine deaminase

Immune system – modulates lymphocyte activity?

NCBI Entrez Gene

Adamts9

2.97

Metalloproteinase inhibitor

Vascular Function - angiogenesis?

PMID: 19052845

Akr1b8

4.49

Unknown

Carcinogen-dependent tumor-associated protein

NCBI Entrez Gene

Asns

2.22

Asparagine synthesis

Cell growth and differentiation – blocks cell proliferation

NCBI Entrez Gene

Bzw2

2.04

Transcription factor?

NCBI Entrez Gene

Cd14

3.14

Binds bacterial lipopolysaccharides

Cell surface protein that mediates monocyte responses to bacterial lipopolysaccharides

NCBI Entrez Gene

Cd93

1.75

Immune system function?

NCBI Entrez Gene

Cyp1b1

2.61

Cytochrome P450 monooxygenases

Lipid metabolism -polycyclic aromatic hydrocarbon, steroid metabolism or phospholipids metabolism

NCBI Entrez Gene

Egfr

2.01

Epidermal growth-factor receptor

Cell growth and differentiation

NCBI Entrez Gene

Eif2b3

1.75

Subunit of initiation factor eIF2B

NCBI Entrez Gene

Emp1

1.88

Epithelial membrane protein 1

NCBI Entrez Gene

Enpp3

3.10

Hydrolysis of extracellular nucleotides

Unknown - Found in immature glia, gut and pancreas

NCBI Entrez Gene

Fcgr3

1.86

Receptor on Fc portion of IgG

Immune system function

NCBI Entrez Gene

Fgl2

3.11

Regulates thrombosis

Vascular endothelium regulation of thrombosis

PMID: 15100314

Fmo5

4.03

N-oxidation of amino-trimethylamine

Fmo5 not well characterized

NCBI Entrez Gene

Foxj1

0.41

Unclear in mammals

Unknown – characterization incomplete

NCBI Entrez Gene

Fst ^b

6.64

Can Inhibit vesicular release of FSH

Adipogenesis? Cancer?

NCBI Entrez Gene PMID19470636

Gda

2.53

Hydrolytic deamination of guanine

Cell signaling? – incomplete characterization

NCBI Entrez Gene

Gja5

2.57

Endothelial gap junction protein

Vascular function - structural integrity

NCBI Entrez Gene

Gpr4

2.20

GCP receptor for lysophosphatidylcholine

May mediate monocyte transmigration through endothelial

NCBI Entrez Gene, PMID17364894

Has1 ^b

7.20

Regulates the biosynthesis of hyaluronan

Immune System - inflammation related?

PMID: 17611197

Ilr2*

5.48

Interleukin 1 receptor family

Inhibits the activity of Il-1

NCBI Entrez Gene

Ilrn*

3.35

Binds to Interleukin 1 receptor

Inhibits the effects of IL-1

NCBI Entrez Gene

Itpkc

2.21

Phosphorylates inositol triphosphate

NCBI Entrez Gene

Lbp

4.15

Binds LPS and interacts with the CD14 receptor

Acute-phase immunologic response to gram-negative bacterial infections

NCBI Entrez Gene

Lrrc4c

0.38

Lrrc4c (NGL1) is a specific binding partner for netrin G1

Has been implicated in axonal guidance

NCBI Entrez Gene

Llgl1

2.14

Non-muscle myosin II heavy chain and a kinase associated

NCBI Entrez Gene

Mt1a ^b

2.77

Protects against oxidative stress

Cardiovascular function - protection from ROS in diabetes?

PMID: 18249147 PMID: 18349110

Mthfd1l

1.94

Synthesis of tetrahydrofolate in the mitochondrion

NCBI Entrez Gene

Ndrg1

2.21

Cytoplasmic protein involved in stress

Involved in endothelial cell migration

PMID: 19760510

Nef3

0.45

Medium neurofilament protein

Biomarker of neuronal damage

NCBI Entrez Gene

Nnij1

1.67

Nerve injury associated protein

NCBI Entrez Gene

Ogfrl1

1.93

Opioid growth factor receptor-like 1

NCBI Entrez Gene

Olfm3

0.42

Associated with lung cancer

NCBI Entrez Gene

Pmp22

1.79

Component of myelin in the peripheral nervous system

NCBI Entrez Gene

Pstpip1

1.76

Immune system-related

NCBI Entrez Gene

Ptprj

1.89

Protein tyrosine phosphatase

Cell cycle and differentiation

NCBI Entrez Gene

Ptges

3.02

Synthesized PGE2

Vascular Function - vasodilatation

NCBI Entrez Gene

Ramp3

2.97

Calcitonin receptor modulating protein

Angiogenesis and vascular integrity

PMID: 18097473

Reg3a

23.49

Extracellular matrix repair?

Inflammation – expressed in pancreatitis and liver cancer damage - function unknown in MAV

NCBI Entrez Gene

Reg3b

27.01

Extracellular matrix repair?

Inflammation – related to pancreatic damage - function unknown in MAV

PMID: 19077460

Reg3g

8.29

Extracellular matrix repair?

Inflammation – related to pancreatic damage and development - function unknown in MAV

NCBI Entrez Gene

Rrp9

1.77

Processing of 18 s rRNA during ribosome synthesis

NCBI Entrez Gene

Rsad2

2.27

Bone formation?

NCBI Entrez Gene

Sct

4.93

Induces gastric relaxation

Endocrine hormone in pancreas and gut – function in MAV may be stimulate bicarbonate secretion

NCBI Entrez Gene

Slc15a1

33.90

Hydrogen peptide co-transporter

Inflammation? – transports polypeptides in intestine - function unknown in MAV

NCBI Entrez Gene PMID: 19462432

Slco4a1*

1.85

Organic anion transporter

NCBI Entrez Gene

Slpi*

6.58

Protects epithelial tissues from serine proteases

NCBI Entrez Gene

Timp1

2.60

Metallopeptidase inhibitor

Multiple functions some vascular-related

NCBI Entrez Gene

Tmem2

2.72

Membrane spanning protein?

Unknown- characterization incomplete

NCBI Entrez Gene

Tmem63c

2.02

Membrane spanning protein?

Unknown- characterization incomplete

NCBI Entrez Gene

Wnt4

1.73

Cell signaling and development

NCBI Entrez Gene